Hu Y, Pang Z, Wang Q, Yang G, Cheng N
Department of Pathology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Hua Xi Yi Ke Da Xue Xue Bao. 2000 Sep;31(3):380-2.
The aim of this study was to evaluate the histologic characteristics of hemangioblastoma (HB) and investigate the histogenesis of its stromal cells. Sixty-eight cases of hemangioblastoma were studied by light microscopy and thirty-three cases were examined by immunohistochemical stainning. Forty-eight of the 68 patients were males and 20 were females. The average age was 37. Fifty-two cases (76.6%) had been present for two months to one year before the diagnosis was made. Sixty cases (88.2%) arose in the cerebellum. Fifty cases (73.5%) appeared as cystic nodules. Histologically, the 68 cases of HB were further categorized into three subtypes: typical (30 cases), cellular (21 cases) and reticular (17 cases). In 33 cases, the stromal cell were positive for NSE, but negative for F-VIII, UEA-1, GFAP and EMA. In summary, there are three essential histologic categories of hemangioblastoma, and its stromal cells may well have the characters of neuroendocrine differentiation.
本研究旨在评估血管母细胞瘤（HB）的组织学特征，并探讨其基质细胞的组织发生。对68例血管母细胞瘤进行了光学显微镜检查，对33例进行了免疫组织化学染色。68例患者中，48例为男性，20例为女性。平均年龄为37岁。52例（76.6%）在诊断前已存在两个月至一年。60例（88.2%）发生于小脑。50例（73.5%）表现为囊性结节。组织学上，68例HB进一步分为三个亚型：典型型（30例）、细胞型（21例）和网状型（17例）。33例中，基质细胞NSE阳性，但F-VIII、UEA-1、GFAP和EMA阴性。总之，血管母细胞瘤有三种基本的组织学类型，其基质细胞很可能具有神经内分泌分化的特征。
