Farzannia Akbar, Shokouhi Ghaffar, Hadidchi Shahram
Department of Neurological Surgery, Tabriz University of Medical Sciences, Tabriz, Iran.
J Neurosurg. 2003 Jan;98(1 Suppl):87-9. doi: 10.3171/spi.2003.98.1.0087.
Alkaptonuria is a rare metabolic disease caused by deficiency of homogentisic acid oxidase and characterized by bluish-black discoloration of cartilages and skin (ochronosis). The authors report the cases of three patients with lumbar disc herniation who underwent discectomy and in whom the nucleus pulposus was discovered to be black. Alkaptonuria was diagnosed after discectomy. Discal herniation requiring surgery is unusual in alkaptonuria, with only a few reports. The symptoms in the three patients disappeared after surgery and no symptoms were demonstrated on follow-up examination.
黑尿症是一种罕见的代谢性疾病，由尿黑酸氧化酶缺乏引起，其特征为软骨和皮肤出现蓝黑色色素沉着（褐黄病）。作者报告了3例腰椎间盘突出症患者行椎间盘切除术的病例，术中发现髓核呈黑色。椎间盘切除术后诊断为黑尿症。在黑尿症中，需要手术治疗的椎间盘突出症并不常见，仅有少数病例报告。这3例患者术后症状消失，随访检查未发现任何症状。
