• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

褐黄病性全髋关节置换术：三例报告

Total Hip Arthroplasty for Ochronosis: A Report of Three Cases.

作者信息

Arasu J Arul Durai, Prasanna A Arul

机构信息

Department of Orthopaedics, JJ Arul Hospital, Dindigul, Tamil Nadu, India.

出版信息

J Orthop Case Rep. 2022 Nov;12(11):23-27. doi: 10.13107/jocr.2022.v12.i11.3400.

DOI:10.13107/jocr.2022.v12.i11.3400
PMID:37013237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10066682/
Abstract

INTRODUCTION

Ochronosis is a rare metabolic disorder, characterized by accumulation of homogentisic acid in the connective tissues due to the lack of the enzyme homogentisic acid oxidase. The musculoskeletal manifestation of alkaptonuria is black pigmentation of cartilage of the knee and the hip leading to arthropathy.

CASE REPORT

In this article, we report three patients with involvement of hip, knee, and spine, but with more severe involvement of the hips. Bilateral hip arthroplasty was done in one out of the three patients.

CONCLUSION

Being a rare disorder and often missed, the functional outcome of hip arthroplasty in these patients is similar to primary osteoarthritis. The importance lies in correct diagnosis and anticipation of intraoperative difficulties.

摘要

引言

褐黄病是一种罕见的代谢紊乱疾病，其特征是由于缺乏尿黑酸氧化酶，导致尿黑酸在结缔组织中蓄积。尿黑酸尿症的肌肉骨骼表现为膝关节和髋关节软骨的黑色色素沉着，进而导致关节病。

病例报告

在本文中，我们报告了3例累及髋关节、膝关节和脊柱的患者，但髋关节受累更为严重。3例患者中有1例行双侧髋关节置换术。

结论

作为一种罕见且常被漏诊的疾病，这些患者髋关节置换术的功能结果与原发性骨关节炎相似。重要的是要做出正确诊断并预见术中困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/99679d1ab122/JOCR-12-23-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/ac36d1a08a96/JOCR-12-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/cf1739393268/JOCR-12-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/630b48859c0e/JOCR-12-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/523051ffeea2/JOCR-12-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/bfdffd526fd3/JOCR-12-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/a1a44443000b/JOCR-12-23-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/b66de84c0fe5/JOCR-12-23-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/99679d1ab122/JOCR-12-23-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/ac36d1a08a96/JOCR-12-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/cf1739393268/JOCR-12-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/630b48859c0e/JOCR-12-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/523051ffeea2/JOCR-12-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/bfdffd526fd3/JOCR-12-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/a1a44443000b/JOCR-12-23-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/b66de84c0fe5/JOCR-12-23-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d32/10066682/99679d1ab122/JOCR-12-23-g008.jpg

相似文献

1
Total Hip Arthroplasty for Ochronosis: A Report of Three Cases.褐黄病性全髋关节置换术：三例报告
J Orthop Case Rep. 2022 Nov;12(11):23-27. doi: 10.13107/jocr.2022.v12.i11.3400.
2
Ochronosis of the hip joint: differential diagnosis of inflammatory arthropathy with lytic lesion.髋关节褐黄病：伴溶骨性病变的炎性关节病的鉴别诊断。
Indian J Clin Biochem. 2014 Jan;29(1):112-3. doi: 10.1007/s12291-013-0340-1. Epub 2013 May 25.
3
Long-term follow-up of bilateral hip and knee arthroplasty secondary to ochronotic arthropathy.褐黄病性关节病继发双侧髋膝关节置换术的长期随访
Arthroplast Today. 2020 Feb 26;6(2):214-219. doi: 10.1016/j.artd.2020.01.012. eCollection 2020 Jun.
4
Cementless total knee arthroplasty in ochronotic arthropathy: a case report with a 4-year follow-up.褐黄病性关节病的非骨水泥型全膝关节置换术：一例4年随访的病例报告
J Arthroplasty. 2000 Jun;15(4):539-43. doi: 10.1054/arth.2000.4228.
5
ARTHROPLASTY IN ALKAPTONURIC OCHRONOSIS.黑尿病性褐黄病的关节成形术
J Popul Ther Clin Pharmacol. 2019 Jul 26;26(2):e20-e24. doi: 10.15586/jptcp.v26i2.624.
6
Long-Term Outcomes of the Knee and Hip Arthroplasties in Patients with Alkaptonuria.黑尿症患者膝关节和髋关节置换术的长期疗效
Arthroplast Today. 2020 Aug 23;6(4):689-693. doi: 10.1016/j.artd.2020.07.037. eCollection 2020 Dec.
7
Intraoperative Diagnosis of a Rare Case of Arthropathy - A Case Report and Review of Literature.罕见关节病的术中诊断——病例报告及文献综述
J Orthop Case Rep. 2020 Nov;10(8):58-62. doi: 10.13107/jocr.2020.v10.i08.1860.
8
Hip arthroplasty for ochronosis.褐黄病性髋关节置换术。
Saudi Med J. 2005 Nov;26(11):1812-4.
9
Bilateral hip arthroplasty for ochronotic arthropathy.针对褐黄病性关节病的双侧髋关节置换术。
Clin Rheumatol. 2000;19(2):150-2. doi: 10.1007/s100670050035.
10
Total knee arthroplasty in ochronosis.褐黄病性全膝关节置换术
Arthroplast Today. 2015 Aug 28;1(3):77-80. doi: 10.1016/j.artd.2015.03.003. eCollection 2015 Sep.

引用本文的文献

1
First Documented Hip Replacement in a Palestinian Patient with Ochronotic Alkaptonuria Arthropathy: A Case Report.巴勒斯坦一名患有褐黄病性黑酸尿症关节病患者首次记录的髋关节置换术：病例报告
J Orthop Case Rep. 2025 Mar;15(3):121-124. doi: 10.13107/jocr.2025.v15.i03.5356.
2
Total Hip Arthroplasty in Ochronotic Arthropathy with quadriceps tear. A Case Report with a Review of the Literature.伴有股四头肌撕裂的褐黄病性关节病的全髋关节置换术。一例病例报告及文献综述
J Orthop Case Rep. 2025 Feb;15(2):80-85. doi: 10.13107/jocr.2025.v15.i02.5236.

本文引用的文献

1
Primary hip arthroplasty for the treatment of alkaptonuric hip arthritis: 3- to 24-year follow-ups.原发性髋关节置换术治疗黑酸尿性髋关节炎：3至24年随访
Arthroplasty. 2019 Oct 3;1(1):8. doi: 10.1186/s42836-019-0010-8.
2
An Unusual Case of Bilateral Ochronotic Arthropathy of the Hip Successfully Managed by a Staged Bilateral Total Hip Replacement- An Insight with a Surgical Note.一例罕见的双侧髋关节褐黄病性关节病经分期双侧全髋关节置换成功治疗——附手术记录分析
J Orthop Case Rep. 2018 Jul-Aug;8(4):11-14. doi: 10.13107/jocr.2250-0685.1136.
3
Knee and Hip Joint Replacement Surgery in a Patient with Ochronotic Arthropathy: Surgical Tips.
褐黄病性关节病患者的膝关节和髋关节置换手术：手术技巧
Arch Bone Jt Surg. 2018 Nov;6(6):577-581.
4
A rare cause of arthropathy: An ochronotic patient with black joints.一种罕见的关节病病因：一位患有黑关节的褐黄病患者。
Int J Surg Case Rep. 2014;5(8):554-7. doi: 10.1016/j.ijscr.2014.06.015. Epub 2014 Jun 27.
5
Ochronosis of the hip joint: differential diagnosis of inflammatory arthropathy with lytic lesion.髋关节褐黄病：伴溶骨性病变的炎性关节病的鉴别诊断。
Indian J Clin Biochem. 2014 Jan;29(1):112-3. doi: 10.1007/s12291-013-0340-1. Epub 2013 May 25.
6
Total hip replacement for an ochronotic patient: A technical trick.褐黄病患者的全髋关节置换术：一项技术技巧。
Am J Case Rep. 2014 Jan 17;15:27-30. doi: 10.12659/AJCR.890008. eCollection 2014.
7
Patients with black hip and black knee due to ochronotic arthropathy: case report and review of literature.因褐黄病性关节病导致髋部和膝部变黑的患者：病例报告及文献综述
Oman Med J. 2013 Nov;28(6):448-9. doi: 10.5001/omj.2013.124.
8
Perioperative management of patient with alkaptonuria and associated multiple comorbidities.患有黑尿症及相关多种合并症患者的围手术期管理
J Anaesthesiol Clin Pharmacol. 2011 Apr;27(2):259-61. doi: 10.4103/0970-9185.81839.
9
Ochronosis of hip joint; a case report.髋关节褐黄病；一例报告。
Cases J. 2009 Dec 16;2:9337. doi: 10.1186/1757-1626-2-9337.
10
Alkaptonuric ochronosis: a case report.尿黑酸尿性褐黄病：一例报告。
AANA J. 2005 Feb;73(1):41-6.