独特型表达与小鼠抗体克隆的遗传
Idiotype expression and the inheritance of mouse antibody clones.
作者信息
Eichmann K
出版信息
J Exp Med. 1973 Mar 1;137(3):603-21. doi: 10.1084/jem.137.3.603.
Abstract
The inheritance of idiotypes was investigated using idiotypic antisera against two monoclonal antibodies to streptococcal carbohydrates derived from A/J mice. Each of the two idiotypes was characterized by a special frequency of expression. One of the idiotypes was expressed in more than 80% of A/J mice, the other in less than 20%. The idiotypes of both antibodies were strain specific and were transmitted to (A/J x BALB/cJ)F(1) hybrid mice. Furthermore, both idiotypes remained associated with the A/J heavy chain C region allotype in (A/J x BALB/cJ)F(1) hybrid mice. The results suggest that idiotypes are specified by allelic V genes, and that the heavy chain idiotype locus is linked to the heavy chain allotype locus.
摘要
利用抗源自A/J小鼠的两种抗链球菌碳水化合物单克隆抗体的独特型抗血清，对独特型的遗传进行了研究。两种独特型中的每一种都具有特殊的表达频率特征。其中一种独特型在超过80%的A/J小鼠中表达，另一种在不到20%的A/J小鼠中表达。两种抗体的独特型具有品系特异性，并传递给（A/J×BALB/cJ）F1杂种小鼠。此外，在（A/J×BALB/cJ）F1杂种小鼠中，两种独特型都与A/J重链C区同种异型相关。结果表明，独特型由等位基因V基因所决定，并且重链独特型基因座与重链同种异型基因座相连。
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