基于五个多标记位点的七个墨西哥本土人群的遗传结构

Genetic structure of seven Mexican indigenous populations based on five polymarker loci.

作者信息

Buentello-Malo Leonora, Peñaloza-Espinosa Rosenda I, Loeza Francisco, Salamanca-Gomez Fabio, Cerda-Flores Ricardo M

机构信息

Instituto de Investigaciónes Antropologicas, Universidad Nacional Autonoma de Mexico, Mexico DF.

出版信息

Am J Hum Biol. 2003 Jan-Feb;15(1):23-8. doi: 10.1002/ajhb.10116.

DOI:10.1002/ajhb.10116

PMID:12552575

Abstract

This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H(T)) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases.

摘要

这项描述性研究基于五个基于聚合酶链反应（PCR）的多态性DNA位点：低密度脂蛋白受体（LDLR）、血型糖蛋白A（GYPA）、β-珠蛋白（HBGG）、D7S8和维生素D结合蛋白（GC），对七个墨西哥本土人群（上米斯特克、下米斯特克、奥托米、普雷佩查、格雷罗州纳瓦人、索奇米尔科纳瓦人以及泽尔塔尔人）的基因结构进行了调查。遗传距离和多样性分析表明，这些墨西哥本土人群具有相似性，并且超过96%的总基因多样性（H(T)）可归因于人群内部的个体差异。上米斯特克、下米斯特克和索奇米尔科纳瓦人显示出与欧洲裔人群有更高程度混合的迹象。所研究标记显示墨西哥印第安人具有相对的基因同质性，这表明该人群适合用于研究疾病标记关联，以寻找复杂疾病的候选基因。