Schmidt M E, Abdelbaki Y Z, Tu A T
J Pathol. 1976 Feb;118(2):75-81. doi: 10.1002/path.1711180203.
The fine structure of renal corpuscles and proximal convoluted tubules of the right kidneys of Suiss mice were studied 9 hr after the injection of the venom of Crotalus atrox (Western diamond-back rattlesnake) or the venom of Laticauda semifasciata (broad-banded blue sea snake). Rattlesnake envenomation resulted in several ultrastructural changes in the renal corpuscles and proximal convoluted tubules. Visceral epithelial changes included intracellular oedema, blebbing, vesiculations, the formation of microvillus projections and dilatation of the endoplasmic reticulum and mitochondria. Changes in the parietal epithelium were similar except that no microvillus projections were noted. Mesangiolysis was a consistent finding. Collagenous fibrils were very prominent in the lysed areas of the mesangial cells. Increased numbers of lysosome-related structures were noted in the proximal convoluted tubule cells. Most of the nuclear cisternae of the cells of the renal corpuscles and proximal convoluted tubules were greatly dilated. Sea snake envenomation resulted in focal organellar swelling and focal intracellular oedema of the visceral epithelium. This venom did not affect the cells of the proximal convoluted tubule. The presence of light and dark visceral epithelial cells has been a consistent finding for both the control and the environmated groups.
在注射了西部菱斑响尾蛇毒液或半环扁尾海蛇毒液9小时后，研究了瑞士小鼠右肾肾小体和近端曲管的精细结构。响尾蛇毒液中毒导致肾小体和近端曲管出现了几种超微结构变化。脏层上皮细胞的变化包括细胞内水肿、起泡、形成小泡、微绒毛突起形成以及内质网和线粒体扩张。壁层上皮细胞的变化相似，只是未观察到微绒毛突起。系膜溶解是一个持续出现的现象。在系膜细胞溶解区域，胶原纤维非常明显。近端曲管细胞中与溶酶体相关的结构数量增加。肾小体和近端曲管细胞的大多数核池显著扩张。海蛇毒液中毒导致脏层上皮细胞出现局灶性细胞器肿胀和局灶性细胞内水肿。这种毒液不影响近端曲管细胞。无论是对照组还是中毒组，始终都能观察到浅色和深色脏层上皮细胞的存在。
