Khedun Shaun M, Naicker Thajasvarie, Moodley Jagdisea
Department of Clinical and Experimental Pharmacology, Nelson R Mandela School of Medicine, Faculty o Health Sciences, University of Natal, South Africa.
J Obstet Gynaecol. 2002 Nov;22(6):590-3. doi: 10.1080/0144361021000020321.
Plasma endothelin-1 activity was measured by radioimmunoassay in 24 normotensive non-pregnant women and in 24 normotensive pregnant, 24-aproteinuric hypertensive and 24 pre-eclamptic women. Endothelin-1 activity was increased in the pre-eclamptic group (2.7 +/- 06 pg/ml) compared to the normotensive non-pregnant (1.0 +/- 0.8 pg/ml; P < 0.0001), normotensive pregnant (1.2 +/- 0.4 pg/ml; P < 0.0001) group and the aproteinuric hypertensive group (1.4 +/- 0.7 pg/ml; P < 0.0001). There was no difference in endothelin-1 activity between the normotensive non-pregnant and normotensive pregnant group (1.0 +/- 0.8 vs. 1.2 +/- 0.4 pg/ml; P = 0.3). However, there was a difference between the aproteinuric hypertensive group (1.4 +/- 0.7 pg/ml) and both the normotensive nonpregnant (1.0 +/- 0.8 pg/ml; P < 0.01) and the normotensive pregnant group (1.2 +/- 0.4 pg/ml; P < 0.06). The birth weight in the pre-eclamptic group (2.48 +/- 0.61 kg) was significantly lower than that of the normotensive pregnant group (2.85 +/- 0.33 kg; P < 0.001) and the aproteinuric hypertensive group (2.99 +/- 0.46 kg; P < 0.001). In addition, there was no difference in birth weight between the normotensive pregnant group and aproteinuric hypertensive group (2.85 +/- 0.33 vs. 2.99 +/- 0.46 kg; P = 0.3). A significant Pearson's correlation of plasma endothelin-l versus birth weight in the pre-eclamptic group was obtained (r = 0.64; P < 0.0001). Endothelin-1 activity is increased with pre-eclampsia in black African women with pre-eclampsia. The results of our study also suggests an ethnic difference in plasma endothelin-1 activity when compared to result of studies carried out in Caucasian women with hypertensive disorders of pregnancy.
采用放射免疫分析法测定了24名血压正常的未孕女性、24名血压正常的孕妇、24名无蛋白尿的高血压女性和24名先兆子痫女性的血浆内皮素-1活性。与血压正常的未孕组（1.0±0.8 pg/ml；P<0.0001）、血压正常的孕妇组（1.2±0.4 pg/ml；P<0.0001）和无蛋白尿的高血压组（1.4±0.7 pg/ml；P<0.0001）相比，先兆子痫组的内皮素-1活性升高（2.7±0.6 pg/ml）。血压正常的未孕组和血压正常的孕妇组之间的内皮素-1活性无差异（1.0±0.8 vs. 1.2±0.4 pg/ml；P=0.3）。然而，无蛋白尿的高血压组（1.4±0.7 pg/ml）与血压正常的未孕组（1.0±0.8 pg/ml；P<0.01）和血压正常的孕妇组（1.2±0.4 pg/ml；P<0.06）之间存在差异。先兆子痫组的出生体重（2.48±0.61 kg）显著低于血压正常的孕妇组（2.85±0.33 kg；P<0.001）和无蛋白尿的高血压组（2.99±0.46 kg；P<0.001）。此外，血压正常的孕妇组和无蛋白尿的高血压组之间的出生体重无差异（2.85±0.33 vs. 2.99±0.46 kg；P=0.3）。先兆子痫组血浆内皮素-1与出生体重之间存在显著的Pearson相关性（r=0.64；P<0.0001）。患有先兆子痫的非洲黑人女性中，内皮素-1活性随先兆子痫而升高。与对患有妊娠高血压疾病的白人女性进行的研究结果相比，我们的研究结果还表明血浆内皮素-1活性存在种族差异。
