Yalti S, Gürbüz B, Fiçicioglu C
Department of Reproductive Endocrinology, Infertility and IVF Unit, Zeynep Kamil Women and Children's Hospital, Istanbul, Turkey.
J Obstet Gynaecol. 2002 Nov;22(6):649-54. doi: 10.1080/0144361021000020466.
Currently, serum inhibin B levels, indicating testicular function due directly to its testicular origin, has been used increasingly in assisted reproductive units. Our aim in this prospective study was to evaluate the biological significance of inhibin B in gonadal dysfunctional males and the usefulness of inhibin B for the detection of male reproductive dysfunction. We included 52 oligoazoospermic and 20 normospermic men in this study. In our study serum inhibin B levels had statistically significant negative correlation with serum FSH and LH levels (P < 0.001, r: 0.781) and statistically moderate positive correlation with oestradiol levels (P < 0.005, r: 0.292). Inhibin B levels had significantly positive correlation with sperm count (P < 1.005, r: 0.851) and with testicular volume (P < 0.001, r: 0.466). Consequently, serum inhibin B level determination is a useful and non-invasive method for the evaluation of male gonadal dysfunction, taking into account its correlation with history, clinical examination, hormonal parameters, testicular volume, spermiogram and testicular biopsy.
目前，血清抑制素B水平因其直接起源于睾丸而可反映睾丸功能，在辅助生殖单位中越来越多地被使用。我们这项前瞻性研究的目的是评估抑制素B在性腺功能障碍男性中的生物学意义以及其在检测男性生殖功能障碍方面的实用性。本研究纳入了52例少弱精子症男性和20例正常精子症男性。在我们的研究中，血清抑制素B水平与血清卵泡刺激素（FSH）和黄体生成素（LH）水平呈统计学显著负相关（P < 0.001，r：0.781），与雌二醇水平呈统计学中度正相关（P < 0.005，r：0.292）。抑制素B水平与精子计数呈显著正相关（P < 0.005，r：0.851），与睾丸体积呈显著正相关（P < 0.001，r：0.466）。因此，考虑到血清抑制素B水平与病史、临床检查、激素参数、睾丸体积、精液分析和睾丸活检的相关性，血清抑制素B水平测定是评估男性性腺功能障碍的一种有用且非侵入性的方法。
