Nguyen-Duy Thanh-Binh, Nichaman Milton Z, Church Timothy S, Blair Steven N, Ross Robert
School of Physical and Health Education, Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Am J Physiol Endocrinol Metab. 2003 Jun;284(6):E1065-71. doi: 10.1152/ajpendo.00442.2002. Epub 2003 Jan 28.
We examined the independent associations among abdominal adipose tissue (AT), liver fat, cardiorespiratory fitness (CRF), and lipid variables in 161 Caucasian men who had a wide variation in adiposity. We measured AT and liver fat by computed tomography and CRF by a maximal exercise test on a treadmill. Visceral AT remained a significant (P <or= 0.05) predictor of plasma triglycerides (TG), high-density-lipoprotein cholesterol (HDL-C), and total cholesterol (TC)/HDL-C ratio (TC/HDL-C) after statistical control for abdominal subcutaneous AT, CRF, and alcohol consumption. Abdominal subcutaneous AT was not a significant (P >or= 0.05) correlate of any lipid variable after control for visceral AT and CRF. Furthermore, subdivision of subcutaneous AT into deep and superficial depots did not alter these observations. Visceral AT was the strongest correlate of liver fat and remained so after control for abdominal subcutaneous AT, CRF, and alcohol consumption (r = -0.34, P < 0.01). In contrast, abdominal subcutaneous AT and CRF were not significant (P > 0.10) correlates of liver fat after control for visceral AT. Visceral AT remained a significant (P < 0.01) correlate of TG, HDL-C, and TC/HDL-C independent of liver fat. However, liver fat was also a significant correlate (P <or= 0.05) of fasting glucose and TG independent of visceral AT. These observations reinforce the importance of visceral obesity in the pathogenesis of dyslipidemia in men, and they suggest that visceral AT and liver fat carry independent health risk.
我们在161名肥胖程度差异较大的白人男性中，研究了腹部脂肪组织（AT）、肝脏脂肪、心肺适能（CRF）和脂质变量之间的独立关联。我们通过计算机断层扫描测量AT和肝脏脂肪，通过跑步机上的最大运动测试测量CRF。在对腹部皮下AT、CRF和饮酒情况进行统计控制后，内脏AT仍然是血浆甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）/HDL-C比值（TC/HDL-C）的显著（P≤0.05）预测因子。在控制内脏AT和CRF后，腹部皮下AT与任何脂质变量均无显著（P≥0.05）相关性。此外，将皮下AT细分为深部和浅部储存库并未改变这些观察结果。内脏AT是肝脏脂肪的最强相关因素，在对腹部皮下AT、CRF和饮酒情况进行控制后仍然如此（r = -0.34，P < 0.01）。相比之下，在控制内脏AT后，腹部皮下AT和CRF与肝脏脂肪无显著（P > 0.10）相关性。内脏AT仍然是TG、HDL-C和TC/HDL-C的显著（P < 0.01）相关因素，与肝脏脂肪无关。然而，肝脏脂肪也是空腹血糖和TG的显著相关因素（P≤0.05），与内脏AT无关。这些观察结果强化了内脏肥胖在男性血脂异常发病机制中的重要性，并表明内脏AT和肝脏脂肪具有独立的健康风险。
