Couch Catharine A, Fowler Lauren A, Goss Amy M, Gower Barbara A
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Int J Cardiol Cardiovasc Risk Prev. 2022 Dec 15;16:200165. doi: 10.1016/j.ijcrp.2022.200165. eCollection 2023 Mar.
Renal sinus fat (RSF) is an ectopic fat depot shown to be associated with visceral adiposity and hypertension in predominantly white populations. The purpose of this analysis is to investigate RSF and associations between RSF and blood pressure in a cohort of African American (AA) and European American (EA) adults. A secondary purpose was to explore risk factors associated with RSF.
Participants were 116 A A and EA adult men and women. Ectopic fat depots were assessed with MRI: RSF, intraabdominal adipose tissue (IAAT), intermuscular adipose tissue (IMAT), perimuscular adipose tissue (PMAT), and liver fat. Cardiovascular measures included diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure, mean arterial pressure, and flow mediated dilation. Matsuda index was calculated for insulin sensitivity. Pearson correlations were used to investigate associations of RSF with cardiovascular measures. Multiple linear regression was used to evaluate contributions of RSF on SBP and DBP and to explore factors associated with RSF.
No difference was observed in RSF between AA and EA participants. RSF was positively associated with DBP in AA participants, but this was not independent of age and sex. Age, male sex, and total body fat were positively associated with RSF in AA participants. Insulin sensitivity was inversely and IAAT and PMAT were positively associated with RSF in EA participants.
Differential associations of RSF with age, insulin sensitivity, and adipose depots among AA and EA adults suggest unique pathophysiological mechanisms influence RSF deposition, which may contribute to chronic disease etiology and progression.
肾窦脂肪（RSF）是一种异位脂肪储存库，在以白人为主的人群中显示与内脏肥胖和高血压有关。本分析的目的是在一组非裔美国（AA）和欧美裔美国（EA）成年人队列中研究肾窦脂肪以及肾窦脂肪与血压之间的关联。第二个目的是探索与肾窦脂肪相关的危险因素。
参与者为116名非裔美国和欧美裔美国成年男性和女性。采用磁共振成像评估异位脂肪储存库：肾窦脂肪、腹内脂肪组织（IAAT）、肌间脂肪组织（IMAT）、肌周脂肪组织（PMAT）和肝脏脂肪。心血管测量指标包括舒张压（DBP）、收缩压（SBP）、脉压、平均动脉压和血流介导的血管舒张。计算松田指数以评估胰岛素敏感性。采用Pearson相关性分析研究肾窦脂肪与心血管测量指标之间的关联。采用多元线性回归评估肾窦脂肪对收缩压和舒张压的影响，并探索与肾窦脂肪相关的因素。
非裔美国和欧美裔美国参与者之间的肾窦脂肪无差异。在非裔美国参与者中，肾窦脂肪与舒张压呈正相关，但这并非独立于年龄和性别。在非裔美国参与者中，年龄、男性性别和全身脂肪与肾窦脂肪呈正相关。在欧美裔美国参与者中，胰岛素敏感性与肾窦脂肪呈负相关，腹内脂肪组织和肌周脂肪组织与肾窦脂肪呈正相关。
非裔美国和欧美裔美国成年人中肾窦脂肪与年龄、胰岛素敏感性和脂肪储存库之间的不同关联表明，独特的病理生理机制影响肾窦脂肪沉积，这可能有助于慢性疾病的病因学和进展。
