Freedland Kenneth E, Rich Michael W, Skala Judith A, Carney Robert M, Dávila-Román Victor G, Jaffe Allan S
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63124, USA.
Psychosom Med. 2003 Jan-Feb;65(1):119-28. doi: 10.1097/01.psy.0000038938.67401.85.
Prevalence estimates of depression in hospitalized patients with congestive heart failure (CHF) differ considerably across studies. This article reports the prevalence of depression in a larger sample of hospitalized patients with CHF and identifies demographic, medical, psychosocial, and methodological factors that may affect prevalence estimates.
A modified version of the Diagnostic Interview Schedule was administered to a series of 682 hospitalized patients with CHF to determine the prevalence of DSM-IV major and minor depression; 613 patients also completed the Beck Depression Inventory. Medical, demographic, and social data were obtained from hospital chart review, echocardiography, and patient interview.
In the sample as a whole, 20% of the patients met the DSM-IV criteria for a current major depressive episode, 16% for a minor depressive episode, and 51% scored above the cutoff for depression on the Beck Depression Inventory (>or=10). However, the prevalence of major depression differed significantly between strata defined by the functional severity of heart failure, age, gender, employment status, dependence in activities of daily living, and past history of major depression. For example, the prevalence ranged from as low as 8% among patients in New York Heart Association class I failure to as high as 40% among patients in class IV.
The prevalence of depression in hospitalized patients with CHF is similar to rates found in post-myocardial infarction patients. However, it is considerably higher in certain subgroups, such as patients with class III or IV heart failure. Further research is needed on the prognostic importance and treatment of comorbid depression in CHF.
不同研究中对充血性心力衰竭(CHF)住院患者抑郁症患病率的估计差异很大。本文报告了更大样本的CHF住院患者中抑郁症的患病率,并确定了可能影响患病率估计的人口统计学、医学、心理社会和方法学因素。
对682例CHF住院患者进行了改良版的诊断访谈表,以确定DSM-IV中重度和轻度抑郁症的患病率;613例患者还完成了贝克抑郁量表。通过医院病历审查、超声心动图和患者访谈获取医学、人口统计学和社会数据。
在整个样本中,20%的患者符合DSM-IV当前重度抑郁发作的标准,16%符合轻度抑郁发作的标准,51%在贝克抑郁量表上的得分高于抑郁症临界值(≥10)。然而,重度抑郁症的患病率在由心力衰竭功能严重程度、年龄、性别、就业状况、日常生活活动依赖程度和既往重度抑郁病史定义的不同层次之间存在显著差异。例如,患病率从纽约心脏协会I级心力衰竭患者中的低至8%到IV级患者中的高达40%不等。
CHF住院患者中抑郁症的患病率与心肌梗死后患者的患病率相似。然而,在某些亚组中,如III级或IV级心力衰竭患者中,患病率要高得多。需要进一步研究CHF中共病抑郁症的预后重要性和治疗方法。