Ricciardolo F L M
Department of Respiratory Disease, Ospedal Riuniti, Bergamo, Italy.
Thorax. 2003 Feb;58(2):175-82. doi: 10.1136/thorax.58.2.175.
Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally, two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect airways from excessive bronchoconstriction while the latter has a modulatory role in inflammatory disorders of the airways such as asthma. This review explores the physiological and pathophysiological role of endogenous nitric oxide in the airways, and the clinical aspects of monitoring nitric oxide in exhaled air of patients with respiratory disease.
一氧化氮由一氧化氮合酶在气道内源性释放。在功能上,该酶存在两种亚型:组成型和诱导型。前者似乎可保护气道免受过度支气管收缩的影响,而后者在气道炎症性疾病如哮喘中起调节作用。本文综述探讨了内源性一氧化氮在气道中的生理和病理生理作用,以及监测呼吸系统疾病患者呼出气中一氧化氮的临床意义。