Caperton E M, Baker D R, King R A
Ann Rheum Dis. 1975 Jun;34(3):231-4. doi: 10.1136/ard.34.3.231.
Lymphocyte function in rheumatoid arthritis has been assessed by the mixed lymphocyte culture assay. In contrast to previous studies, no difference was found between lymphocytes from healthy volunteers and patients with rheumatoid arthritis. An occasional patient's lymphocytes failed to respond on a given day, but were normal on restudy. All 44 arthritic patient's lymphocytes underwent blast transformation on stimulation with lymphocytes from unrelated donors. By reaction in mixed lymphocyte culture, lymphocytes from patients with rheumatoid arthritis appear to be normal and no different from normal cells studied simultaneously.
类风湿性关节炎中的淋巴细胞功能已通过混合淋巴细胞培养试验进行评估。与先前的研究不同,在健康志愿者和类风湿性关节炎患者的淋巴细胞之间未发现差异。偶尔有患者的淋巴细胞在某一天无反应,但再次检测时正常。所有44名关节炎患者的淋巴细胞在用无关供体的淋巴细胞刺激后均发生了母细胞转化。通过混合淋巴细胞培养中的反应,类风湿性关节炎患者的淋巴细胞似乎是正常的,与同时研究的正常细胞没有差异。