Bailey D J, Doggett N S, Ng L Y, Qazi T
J Med Chem. 1976 Mar;19(3):438-9. doi: 10.1021/jm00225a024.
During the investigation of a series of spiro compounds having approximately similar molecular dimensions to naturally occurring estrogens, the novel compound spiro(cyclohexane-1,2'-indan)-1',4-dione was prepared. The pretreatment of mice with this estrogenically inactive compound was found to potentiate the estrogenic activity of stilbestrol.
在对一系列分子尺寸与天然存在的雌激素大致相似的螺环化合物进行研究期间，制备了新型化合物螺（环己烷 - 1,2'-茚满）-1',4-二酮。发现用这种无雌激素活性的化合物对小鼠进行预处理可增强己烯雌酚的雌激素活性。
