Liu F, Wu J
Department of Biology, Dental School, Fourth Military Medical University, Xi'an 710032.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2000 Jun;17(2):223-5, 230.
Artificial skin is a kind of skin which by using tissue engineering techniques, a skin-like material was formed by seeding epithelium cells and dermis fibroblasts on a good biocompatible material after proliferation. The trauma restoration and reconstruction were achieved by transplanting the skin graft an skin defects after the artificial skin graft cultured in vitro. Artificial skin research is a new active field in tissue engineering. It has wonderful prospect for clinics to radically settle the problem of restoration of skin defects. The recent studies on the models, cultured methods and influenced factors for epithium culture, dermis culture and artificial skin in vitro were reviewed in this paper.
人工皮肤是一种利用组织工程技术，将上皮细胞和成纤维细胞接种在具有良好生物相容性的材料上，经增殖后形成的类似皮肤的材料。体外培养人工皮肤后，通过将其移植到皮肤缺损处来实现创伤修复和重建。人工皮肤研究是组织工程领域一个新的活跃方向。从根本上解决皮肤缺损修复问题，在临床上有着广阔的前景。本文综述了近年来上皮细胞培养、真皮培养及体外人工皮肤的模型、培养方法和影响因素的研究。
