一种用于烯丙基保护基的温和脱保护策略及其在序列特异性树枝状大分子合成中的意义。
A mild deprotection strategy for allyl-protecting groups and its implications in sequence specific dendrimer synthesis.
作者信息
Vutukuri Dharma Rao, Bharathi Pandi, Yu Zhouying, Rajasekaran Karthik, Tran My-Huyen, Thayumanavan S
机构信息
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
出版信息
J Org Chem. 2003 Feb 7;68(3):1146-9. doi: 10.1021/jo026469p.
A mild deprotection strategy for allyl ethers under basic conditions in the presence of a palladium catalyst is described. Under these conditions, aryl allyl ethers can be cleaved selectively in the presence of alkyl allyl ethers. These conditions are also effective in the deprotection of allyloxycarbonyl groups. The utility of the current methodology in sequence specific dendrimer synthesis is demonstrated.
本文描述了一种在碱性条件下，钯催化剂存在时烯丙基醚的温和脱保护策略。在这些条件下，芳基烯丙基醚可以在烷基烯丙基醚存在下选择性地裂解。这些条件对于烯丙氧羰基的脱保护也很有效。本文还展示了当前方法在序列特异性树枝状大分子合成中的实用性。
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