Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
J Am Chem Soc. 2017 Mar 1;139(8):2880-2883. doi: 10.1021/jacs.6b12708. Epub 2017 Feb 14.
Methods for the direct C-H functionalization of aromatic compounds are in demand for a variety of applications, including the synthesis of agrochemicals, pharmaceuticals, and materials. Herein, we disclose the construction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. The reaction proceeds at room temperature under mild conditions and has proven to be compatible with a variety of electron-donating and -withdrawing groups, halogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceutical agents.
方法的直接 C-H 功能化的芳香族化合物的需求有各种各样的应用,包括合成农药、药品和材料。在此，我们披露的构建芳族腈通过直接 C-H 功能化使用吖啶光氧化还原催化剂和三甲基硅氰化物在有氧气氛下。反应在室温下温和的条件下进行，并已被证明与各种供电子和吸电子基团，卤素，氮和氧杂环，以及芳香族药物。
