Ozdemir Nezih, Kara Murat, Dikmen Erkan, Nadir Aydin, Akal Murat, Yücemen Nezih, Yavuzer Sinasi
Department of Thoracic Surgery, Ankara University Faculty of Medicine, Ibn-i Sina Hospital, 06100, Sihhiye, Ankara, Turkey.
Eur J Cardiothorac Surg. 2003 Feb;23(2):233-7. doi: 10.1016/s1010-7940(02)00744-3.
Thymectomy remains as the optimal treatment of choice in patients with myasthenia gravis (MG), however, the selection criteria for surgery remains controversial.
We examined the data charts of patients with MG underwent extended thymectomy. We investigated the possible correlations between the clinicopathologic features and clinical outcomes, and analyzed the data to clarify the effect of prognostic factors on clinical outcome.
A total of 61 patients with a mean age of 35.8 +/- 12.2 years (range, 13-66 years) were analyzed. The overall improvement/remission and clinical worsening rates were 81.9 and 18.1%, respectively. Ossermann stage (P = 0.011) and presence of mediastinal ectopic thymic tissue (P = 0.007) showed a significant correlation with the clinical outcome. Multivariate analysis confirmed Ossermann stage (P = 0.0158), and presence of mediastinal ectopic thymic tissue (P = 0.0100) as independent predictors on clinical outcome.
Ossermann stage and the presence of mediastinal ectopic thymic tissue are potential predictors on clinical outcome in patients with MG undergoing extended thymectomy.
胸腺切除术仍是重症肌无力（MG）患者的最佳治疗选择，然而，手术的选择标准仍存在争议。
我们检查了接受扩大胸腺切除术的MG患者的数据图表。我们研究了临床病理特征与临床结果之间可能的相关性，并分析数据以阐明预后因素对临床结果的影响。
共分析了61例患者，平均年龄为35.8±12.2岁（范围13 - 66岁）。总体改善/缓解率和临床恶化率分别为81.9%和18.1%。Ossermann分期（P = 0.011）和纵隔异位胸腺组织的存在（P = 0.007）与临床结果显示出显著相关性。多因素分析证实Ossermann分期（P = 0.0158）和纵隔异位胸腺组织的存在（P = 0.0100）是临床结果的独立预测因素。
Ossermann分期和纵隔异位胸腺组织的存在是接受扩大胸腺切除术的MG患者临床结果的潜在预测因素。
