Ashour M
King Khalid University Hospital, Riyadh, Saudi Arabia.
J Thorac Cardiovasc Surg. 1995 Apr;109(4):632-5. doi: 10.1016/S0022-5223(95)70343-8.
Forty patients with myasthenia gravis underwent maximal thymectomy. Complete histologic study findings were available for 38 patients. The prevalence of ectopic thymic tissue was 39.5% (15 of 38). On the basis of the presence or absence of ectopic thymic tissue, patients were divided into two groups: group I had ectopic thymic tissue and group II had no ectopic thymic tissue. Male/female ratio was almost equal (1.1:1) in group I, whereas in group II the ratio was 1:2.8. The duration of the disease was less than 1 year in 80% of group I and 47.8% of group II patients (p = 0.05). Furthermore, ectopic thymic tissue (group I) was associated with poor outcome of operation (p = 0.003). Only 2 (13.3%) of 15 patients in group I had complete remission as compared with 11 (47.8%) of 23 patients in group II. Thus it appears that the presence of ectopic thymic tissue not only modifies some of the clinical parameters of myasthenia gravis, but also could serve as a prognostic factor in predicting the outcome of operation.
40例重症肌无力患者接受了最大程度的胸腺切除术。38例患者有完整的组织学研究结果。异位胸腺组织的发生率为39.5%（38例中的15例）。根据有无异位胸腺组织，将患者分为两组：I组有异位胸腺组织，II组无异位胸腺组织。I组的男女比例几乎相等（1.1:1），而II组的比例为1:2.8。I组80%的患者和II组47.8%的患者病程小于1年（p = 0.05）。此外，异位胸腺组织（I组）与手术效果不佳相关（p = 0.003）。I组15例患者中只有2例（13.3%）完全缓解，而II组23例患者中有11例（47.8%）完全缓解。因此，异位胸腺组织的存在似乎不仅改变了重症肌无力的一些临床参数，而且还可作为预测手术结果的一个预后因素。
