Province Michael A, Kardia Sharon L R, Ranade Koustubh, Rao Dabeeru C, Thiel Bonnie A, Cooper Richard S, Risch Neil, Turner Stephen T, Cox David R, Hunt Steven C, Weder Alan B, Boerwinkle Eric
Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Am J Hypertens. 2003 Feb;16(2):144-7. doi: 10.1016/s0895-7061(02)03248-x.
Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives).
The evidence was synthesized using meta-analysis.
Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage.
No regions show uniformly large effects on BP/hypertension in all populations.
四个多中心网络（基因网络、热那亚、高血压基因研究、蓝宝石）构成了美国国立心肺血液研究所家族血压项目（FBPP），旨在寻找高血压/血压（BP）基因。这些网络采用了不同的家族设计，并针对多个种族群体，使用标准化方案和定义。在每个网络内的样本（N = 6245名亲属）上进行了连锁基因组扫描。
使用荟萃分析综合证据。
合并各民族数据后，没有区域达到LOD>2，但识别出了几个小峰值，包括2号染色体p区域，最近的另外两份报告在该区域发现了高血压连锁。
没有区域在所有人群中对血压/高血压均显示出一致的显著影响。
