Hadfield Pandora J, Albert David M, Bailey C Martin, Lindley Keith, Pierro Agostino
Department of Paediatric Otolaryngology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Int J Pediatr Otorhinolaryngol. 2003 Jan;67(1):11-4. doi: 10.1016/s0165-5876(02)00284-7.
to investigate whether relief of airway obstruction in laryngomalacia by aryepiglottoplasty affects gastro-oesophageal reflux.
a prospective study of consecutive infants and children with suspected laryngomalacia. Gastro-oesophageal reflux was measured before and after diagnostic microlaryngobronchoscopy and aryepiglottoplasty.
of the six cases who underwent aryepiglottoplasty and completed the study, three had significant pre-operative reflux according to age. In this group the reflux improved significantly after aryepiglottoplasty. In the other three cases, reflux was not age-significant pre-operatively nor did it change significantly post-operatively.
when partial airway obstruction due to laryngomalacia co-exists with gastro-oesophageal reflux, treatment of the airway problem improves respiratory symptoms in all cases and reduces gastro-oesophageal reflux in patients with age-significant reflux. This suggests that there are two clinical groups, those with severe, age-significant reflux, possibly caused by airway obstruction, whose gastro-oesophageal reflux benefits from aryepiglottoplasty; and those whose reflux is physiological and not influenced by aryepiglottoplasty. Therefore aryepiglottoplasty can be expected to reduce gastro-oesophageal reflux in those infants with laryngomalacia who have age-significant reflux.
探讨会厌成形术缓解喉软化症气道梗阻是否会影响胃食管反流。
对连续的疑似喉软化症的婴幼儿进行前瞻性研究。在诊断性显微喉镜检查和会厌成形术前及术后测量胃食管反流情况。
接受会厌成形术并完成研究的6例患者中,3例根据年龄有明显的术前反流。在该组中,会厌成形术后反流明显改善。在其他3例中,术前反流与年龄无关,术后也无明显变化。
当喉软化症导致的部分气道梗阻与胃食管反流并存时,气道问题的治疗可改善所有患者的呼吸症状,并减轻有明显年龄相关反流患者的胃食管反流。这表明存在两个临床组,一组是严重的、有明显年龄相关反流的患者,可能由气道梗阻引起,其胃食管反流可从会厌成形术中获益;另一组反流是生理性的,不受会厌成形术影响。因此,预计会厌成形术可减少那些有明显年龄相关反流的喉软化症婴儿的胃食管反流。