Lu Xiao-Lan, Yi Wei-Min, Wang Lan-Fen
Department of Obstetrics and Gynecology, Shanghai Municipal Corps Hospital, Chinese People's Armed Police Forces, Shanghai, 201103, P. R. China. lu-xiao
Ai Zheng. 2003 Jan;22(1):62-5.
BACKGROUND & OBJECTIVE: It has been showed that cellular DNA content and silver-staining nucleolar organizer region (AgNOR) count were significantly associated with the prognosis of some tumors; however, it is not yet clear whether these two parameters be helpful in predicting the prognosis of ovarian cystadenoma. This study was designed to evaluate the prognostic significance of these two parameters in ovarian cystadenoma.
Cellular DNA content and AgNOR count of the tumor cells for the samples from 42 patients with ovarian cystadenoma were measured by using computerized image analysis. The relationship between clinical as well as histomorphologic factors and the overall survival was evaluated by multivariable analysis.
Univariate analysis showed that AgNOR count, DNA index, FIGO stage, degree of differentiation, presence of distant metastasis, residual tumor, lymph node metastasis, and age were the clinical variates with significant difference (P < 0.05). Multivariate analysis showed that DNA index > 1.4, FIGO stage, degree of differentiation, and residual tumor were prognostic predictors of ovarian cystadenoma.
The DNA index may be a useful independent factor for predicting the diagnosis of ovarian cystadenoma.
已有研究表明，细胞DNA含量和银染核仁组织区（AgNOR）计数与某些肿瘤的预后显著相关；然而，这两个参数是否有助于预测卵巢囊腺瘤的预后尚不清楚。本研究旨在评估这两个参数在卵巢囊腺瘤中的预后意义。
采用计算机图像分析技术，对42例卵巢囊腺瘤患者样本的肿瘤细胞进行细胞DNA含量和AgNOR计数测定。通过多变量分析评估临床及组织形态学因素与总生存期的关系。
单因素分析显示，AgNOR计数、DNA指数、国际妇产科联盟（FIGO）分期、分化程度、远处转移、残留肿瘤、淋巴结转移和年龄等临床变量存在显著差异（P<0.05）。多变量分析显示，DNA指数>1.4、FIGO分期、分化程度和残留肿瘤是卵巢囊腺瘤的预后预测指标。
DNA指数可能是预测卵巢囊腺瘤诊断的一个有用的独立因素。
