Liu C, Zhao Y, Sun X
Affiliate Hospital of Qingdao Medical College.
Zhonghua Fu Chan Ke Za Zhi. 1995 Dec;30(12):738-40.
To study nuclear DNA content and morphological parameters in ovarian cystadenocarcinoma.
Nuclear DNA content and morphological parameters were quantitatively determined by image analysis technology in 56 cases of ovarian cystadenocarcinoma, 12 benign ovarian cystadenoma and 10 normal ovarian epithelial tissue.
DNA content of ovarian cystadenocarcinoma was the highest among the three groups; and there were significant differences between the groups (P < 0.01). In the aspect of morphometry, nuclear circle was greatly different among the three groups (P < 0.01). There was no significant variances in nuclear parameter and area (P > 0.05). Nuclear DNA content of ovarian cystadenocarcinoma was related to its histopathological classification, histological grade and clinical stages (P < 0.01, P < 0.05). There was a reverse relationship between the DNA ploidy level and clinical prognosis. The 2-year survival rate of ovarian cystadenocarcinoma with diploidy/near diploidy pattern was higher than that with aneuploid pattern (P < 0.01).
Nuclear DNA content of ovarian cystadenocarcinoma is a useful marker in reflecting the biological behavior and is of practical value in diagnosis, the choice of treatment methods and in the evaluation of results and prognosis.
研究卵巢囊腺癌的核DNA含量及形态学参数。
采用图像分析技术对56例卵巢囊腺癌、12例良性卵巢囊腺瘤及10例正常卵巢上皮组织进行核DNA含量及形态学参数的定量测定。
卵巢囊腺癌的DNA含量在三组中最高，组间差异有统计学意义（P < 0.01）。在形态测量方面，三组间核圆形度差异有统计学意义（P < 0.01），核参数及面积差异无统计学意义（P > 0.05）。卵巢囊腺癌的核DNA含量与其组织病理学分类、组织学分级及临床分期相关（P < 0.01，P < 0.05）。DNA倍体水平与临床预后呈负相关。二倍体/近二倍体模式的卵巢囊腺癌2年生存率高于非整倍体模式（P < 0.01）。
卵巢囊腺癌的核DNA含量是反映生物学行为的有用标志物，对诊断、治疗方法的选择及结果和预后评估具有实际价值。
