El-Bishlawy I, Aly S M, Fahmy I A
Tropical Medicine Research Institute, Ministry of Health and Population, Cairo 11566, Egypt.
J Egypt Soc Parasitol. 1999;29(1):25-34.
Because of the socio-economic condition of African countries, the traditional types of vaccines should be encouraged. LTV in a preliminary study, proved to be of value in reducing morbidity and mortality in Schistosoma mansoni infection. In the present study and because of the vaccine contains liver tissue homogonate, the present authors analyed the DNA content of the hepatocytes of the vaccinated and control groups of animals to know any effects of the vaccine on the hepatocytes ploidy. The DNA content of vaccinated animals was higher. The results were discussed. It was concluded that for testing S. mansoni vaccine, DNA analysis of heptocytes for detecting proliferative S-phase is an important as a positive immune reaction.
由于非洲国家的社会经济状况，应鼓励使用传统类型的疫苗。在一项初步研究中，减毒活疫苗被证明在降低曼氏血吸虫感染的发病率和死亡率方面具有价值。在本研究中，由于该疫苗含有肝组织匀浆，作者分析了接种疫苗组和对照组动物肝细胞的DNA含量，以了解该疫苗对肝细胞倍性的任何影响。接种疫苗动物的DNA含量较高。对结果进行了讨论。得出的结论是，对于曼氏血吸虫疫苗的检测，用于检测增殖性S期的肝细胞DNA分析与阳性免疫反应一样重要。
