Eissa M M, Allam S R, el Azzouni M Z, Baddour N M
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
J Egypt Soc Parasitol. 1998 Aug;28(2):461-79.
The efficacy of autoclaved cercarial vaccine (ACV) in eliciting protective immunity against Schistosoma mansoni infection was investigated in Swiss strain Albino mice. Two main groups of animals were used. One served as control group and the second was vaccinated with ACV mixed with Bacille Clamette-Guerin (BCG) as an adjuvant, in a single, double and triple doses 2 weeks apart. Six weeks after the first vaccination, all animals were challenged with freshly liberated cercariae of Schistosoma mansoni then sacrificed 7 weeks later. Parasitological, histopathological and immunological studies showed promising results which gave hope in evolution of anti-schistosomal vaccine.
在瑞士品系白化小鼠中研究了高压灭菌尾蚴疫苗（ACV）诱导针对曼氏血吸虫感染的保护性免疫的效果。使用了两组主要动物。一组作为对照组，另一组用与卡介苗（BCG）混合作为佐剂的ACV进行接种，分别以单剂量、双剂量和三剂量，间隔2周接种。首次接种6周后，所有动物均用新逸出的曼氏血吸虫尾蚴进行攻击，然后在7周后处死。寄生虫学、组织病理学和免疫学研究显示出有希望的结果，这为抗血吸虫疫苗的发展带来了希望。
