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去铁胺单独及联合乙胺嘧啶对小鼠急性弓形虫病的影响。

Effect of deferoxamine alone and combined with pyrimethamine on acute toxoplasmosis in mice.

作者信息

Mahmoud M S

机构信息

Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.

出版信息

J Egypt Soc Parasitol. 1999;29(3):791-803.

Abstract

The standard regimen of treatment for toxoplasmosis is pyrimethamine with sulfadiazine. However, it is not suitable in some conditions, and nontolerable in AIDS patients. Deferoxamine (DFO), an iron chelator, is well tolerated clinically in transfusion induced - iron overload. The present study had shown that DFO is a promising drug against acute toxoplasmosis in mice. Three doses of 200, 300 and 400 mg/kg DFO were used either alone or in combination with pyrimethamine. Alone, it was effective in a dose- related response with the resultant of 70% protection of infected mice. When DFO was combined with a low minimally effective dose of pyrimethamine, a 100% protection was recorded with the prolongation in duration of survival of mice. Different possible mechanisms of action of DFO against Toxoplasma gondii were discussed.

摘要

弓形虫病的标准治疗方案是乙胺嘧啶联合磺胺嘧啶。然而,在某些情况下它并不适用,在艾滋病患者中也无法耐受。去铁胺(DFO)是一种铁螯合剂,在输血引起的铁过载患者中临床耐受性良好。目前的研究表明,DFO是一种对小鼠急性弓形虫病有前景的药物。使用了200、300和400mg/kg三种剂量的DFO,单独使用或与乙胺嘧啶联合使用。单独使用时,它呈现剂量相关反应,可使70%的感染小鼠得到保护。当DFO与低剂量的最低有效剂量乙胺嘧啶联合使用时,可实现100%的保护,并延长小鼠的存活时间。文中还讨论了DFO对抗刚地弓形虫的不同可能作用机制。

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