Wellcome Centre for Integrative Parasitology, Institute for Infection, Immunity and Inflammation, University of Glasgow, UK.
Microbiology (Reading). 2021 Dec;167(12). doi: 10.1099/mic.0.001114.
The acquisition and storage of metals has been a preoccupation of life for millennia. Transition metals, in particular iron, copper and zinc, have vital roles within cells. However, metals also make dangerous cargos; inappropriate uptake or storage of transition metals leads to cell death. This paradox has led to cells developing elegant and frequently redundant mechanisms for fine-tuning local metal concentrations. In the context of infection, pathogens must overcome further hurdles, as hosts act to weaponize metal availability to prevent pathogen colonization and spread. Here, we detail the methods used by the Apicomplexa, a large family of eukaryotic parasites, to obtain and store essential metals.
金属的获取和储存是生命几千年来关注的焦点。过渡金属，特别是铁、铜和锌，在细胞中起着至关重要的作用。然而，金属也是危险的货物;过渡金属的不当摄取或储存会导致细胞死亡。这种矛盾导致细胞形成了精致而常常冗余的机制来微调局部金属浓度。在感染的情况下，病原体必须克服更多的障碍，因为宿主会利用金属的可用性来武装自己，以防止病原体的定植和传播。在这里，我们详细描述了原生动物，一个大型的真核寄生虫家族，获取和储存必需金属的方法。
