Trotta Maria Paola, Ammassari Adriana, Melzi Sara, Zaccarelli Mauro, Ladisa Nicoletta, Sighinolfi Laura, Mura Maria Stella, d'Arminio Monforte Antonella, Antinori Andrea
Istituto Nazionale per le Malattie Infettive, L. Spallanzani IRCCS, Roma, Italy.
J Acquir Immune Defic Syndr. 2002 Dec 15;31 Suppl 3:S128-31. doi: 10.1097/00126334-200212153-00008.
Adherence to highly active antiretroviral therapy (HAART) plays a critical role in the effectiveness of HIV treatment. Nevertheless, the complexity of regimens and frequent side effects make HAART extraordinarily difficult to take, and many HIV-infected persons fail to adhere. The current study offers an overview of the relationship between adherence and antiretroviral treatment-related variables. As for other chronic diseases, medication regimen complexity also has an impact on adherence in the management of HIV infection. In particular, the authors discuss the effect of pill burden, dosing frequency, dietary instructions, number and type of different medications prescribed, short- and long-term side effects, convenience, and ability to incorporate the treatment regimen into a daily routine. Medication side effects are common in HAART-treated persons and are associated with concurrent and future nonadherence. Simplification of regimens, adjustment of the drug schedule to the patient's specific lifestyle, and anticipation and self-management of side effects are treatment-based strategies to optimize HAART adherence and ensure the most effective, convenient, safe, and well-tolerated antiretroviral treatment.
坚持高效抗逆转录病毒疗法（HAART）在HIV治疗效果中起着关键作用。然而，治疗方案的复杂性和频繁的副作用使得HAART极难坚持服用，许多HIV感染者无法坚持治疗。当前的研究概述了坚持治疗与抗逆转录病毒治疗相关变量之间的关系。与其他慢性疾病一样，用药方案的复杂性也会影响HIV感染管理中的治疗依从性。特别是，作者讨论了药片负担、给药频率、饮食说明、所开不同药物的数量和类型、短期和长期副作用、便利性以及将治疗方案融入日常生活的能力等因素的影响。药物副作用在接受HAART治疗的人群中很常见，并且与当前及未来的治疗不依从相关。简化治疗方案、根据患者的特定生活方式调整用药时间表以及对副作用的预期和自我管理是以治疗为基础的策略，可优化HAART治疗的依从性，并确保抗逆转录病毒治疗最有效、方便、安全且耐受性良好。
