短穗黄芪中的抗菌二萜类化合物

Antibacterial diterpenoids from Astragalus brachystachys.

作者信息

Jassbi Amir Reza, Zamanizadehnajari Simin, Azar Parviz Aberoomand, Tahara Satoshi

机构信息

Laboratory of Ecological Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan.

出版信息

Z Naturforsch C J Biosci. 2002 Nov-Dec;57(11-12):1016-21. doi: 10.1515/znc-2002-11-1211.

DOI:10.1515/znc-2002-11-1211

PMID:12562087

Abstract

Antibacterial bioassay guided fractionation of acetone extracts of Astragalus brachystachys resulted in isolation of sclareol and two related labdane-type diterpenoids, 14R-epoxysclareol and 6beta-hydroxysclareol. The antibacterial activity of the isolated compounds was measured and it was deduced that the epoxidation at the double bond of sclareol or hydroxylation at C-6 decreased the activity of the resulting compounds. Salvigenin (5-hydroxy-4',6,7-trimethoxyflavone) was also separated from this plant for the first time.

摘要

对短穗黄芪丙酮提取物进行抗菌生物测定引导的分馏，分离出了香紫苏醇以及两种相关的半日花烷型二萜类化合物，14R-环氧香紫苏醇和6β-羟基香紫苏醇。对分离出的化合物的抗菌活性进行了测定，结果表明香紫苏醇双键处的环氧化或C-6位的羟基化会降低所得化合物的活性。还首次从该植物中分离出了 salvigenin（5-羟基-4',6,7-三甲氧基黄酮）。