Jackson R, Grainge J W
Can Med Assoc J. 1975 Sep 6;113(5):396-401.
Palmar and plantar keratoses developed in seven patients many years after ingeston of trivalent inorganic arsenic. Six had basal cell carcinoma (superficial multicentric type in five), carcinoma "in situ" or squamous cell carcinoma of the skin. Two had systemic carcinoma--one, bilateral breast adenocarcinoma and one, carcinoma of the colon. From these observations and from the findings of a review of the literature, there seems no question that long-term arsenic ingestion can cause palmar and plantar keratoses and skin cancer, particularly basal cell carcinoma of the superficial multicentric type, usually on the torso. It is suspected but not proved to cause other cancers. Although over the last 50 years general exposure to arsenic has greatly decreased, particularly that from insecticides, this element is still found occasionally in drinking water (naturally or as a smelter byproduct), in certain foods and in cigarette smoke.
7名患者在摄入三价无机砷多年后出现了掌跖角化病。其中6例患有基底细胞癌（5例为浅表多中心型）、皮肤原位癌或鳞状细胞癌。2例患有全身性癌症——1例为双侧乳腺腺癌，1例为结肠癌。从这些观察结果以及文献综述的发现来看，长期摄入砷会导致掌跖角化病和皮肤癌，尤其是浅表多中心型基底细胞癌，通常发生在躯干上，这似乎是毫无疑问的。人们怀疑但尚未证实它会引发其他癌症。尽管在过去50年中，砷的总体暴露量已大幅下降，尤其是来自杀虫剂的暴露，但这种元素仍偶尔在饮用水中（天然存在或作为冶炼厂副产品）、某些食物和香烟烟雾中被发现。
