Padmanabhan Vijayalakshmi, Trainer Thomas D
Department of Pathology, University of Vermont, Burlington, USA.
Arch Pathol Lab Med. 2003 Feb;127(2):E64-6. doi: 10.5858/2003-127-e64-SAAMCL.
Synchronous occurrence of malignant lymphoma and carcinoma, both located in the intestinal tract, is unusual. We report a unique case of an adenocarcinoma of the cecum and a simultaneous mantle cell lymphoma of the colon, terminal ileum, and regional lymph nodes in an 85-year-old man. Grossly, the adenocarcinoma was identified as a cecal mass. Lymphomatous involvement of the gastrointestinal tract was evident only on microscopic examination. The terminal ileum and colon showed microscopic disseminated multiple mucosal nodules, with involvement of the regional lymph nodes. There was no involvement of distant organs, suggesting that the mantle cell lymphoma was early in its evolution without formation of polyps or a mass lesion. To our knowledge, this is the fourth reported case with this association and the second case that showed early involvement of the gastrointestinal tract with mantle cell lymphoma without polyp formation.
恶性淋巴瘤和癌同时发生且均位于肠道的情况并不常见。我们报告了一例独特病例，一名85岁男性患有盲肠腺癌，同时结肠、回肠末端及区域淋巴结存在套细胞淋巴瘤。大体上，腺癌表现为盲肠肿物。胃肠道的淋巴瘤累及仅在显微镜检查时才明显。回肠末端和结肠可见显微镜下弥漫性多发黏膜结节，并累及区域淋巴结。未累及远处器官，提示套细胞淋巴瘤尚处于早期演变阶段，未形成息肉或肿块病变。据我们所知，这是第四例报道的这种关联病例，也是第二例显示胃肠道早期被套细胞淋巴瘤累及且无息肉形成的病例。
