Saito Makoto, Egami Hiroki, Kato Takashi, Yokoyama Emi, Izumiyama Koh, Mori Akio, Morioka Masanobu, Kondo Takeshi, Tanei Zen-Ichi
Blood Disorders Center, Aiiku Hospital, Sapporo, Hokkaido 064-0804, Japan.
Department of Gastroenterology, Aiiku Hospital, Sapporo, Hokkaido 064-0804, Japan.
Mol Clin Oncol. 2022 Jun 21;17(2):129. doi: 10.3892/mco.2022.2562. eCollection 2022 Aug.
Colorectal follicular lymphoma (FL) is rare. In addition, it is even rarer that colon cancer develops synchronously with colorectal lymphoma. The present study reports a case of sigmoid colon cancer that developed 6 months after endoscopic resection of rectal FL. A 71-year-old man with a history of developing mucosa-associated lymphoid tissue lymphoma in his stomach at age 48, right neck region at age 59 (the latter later modified as FL) and lung adenocarcinoma at age 60 now suffers from rectal FL. Endoscopic submucosal dissection (ESD) was performed at our hospital (Aiiku Hospital), and 6 months after the treatment, sigmoid colon cancer was confirmed by colonoscopy for the follow-up study. The patient was successfully curatively resected by ESD plus local resection and has survived without a recurrence for >3 years with no treatment. It was speculated that in the present case, cancer-related genes were changed as a carcinogenic mechanism due to decreased immune function associated with the onset of lymphoma.
结直肠滤泡性淋巴瘤（FL）较为罕见。此外，结肠癌与结直肠淋巴瘤同步发生的情况更为罕见。本研究报告了1例在直肠FL内镜切除术后6个月发生的乙状结肠癌病例。一名71岁男性，48岁时曾患胃黏膜相关淋巴组织淋巴瘤，59岁时患右颈部淋巴瘤（后诊断为FL），60岁时患肺腺癌，现患有直肠FL。在我院（爱育医院）进行了内镜下黏膜下剥离术（ESD），治疗6个月后，结肠镜检查随访发现乙状结肠癌。该患者通过ESD加局部切除术成功实现根治性切除，未经治疗已存活超过3年且无复发。据推测，在本病例中，与淋巴瘤发病相关的免疫功能下降导致癌症相关基因发生改变，这是致癌机制。
