Martignoni Guido, Eble John N
Dipartimento di Patologia-Sezione Anatomia Patologica, Universita' di Verona, Verona, Italy.
Arch Pathol Lab Med. 2003 Jan;127(1):e22-4. doi: 10.5858/2003-127-e22-CTOTU.
We report the clinical, histopathologic, and immunophenotypic features of 2 carcinoid tumors of the urinary bladder and review the literature. Both tumors were located in the bladder neck, presented with hematuria, were small, and appeared to be completely excised cystoscopically. The tumors were smooth-surfaced sessile polypoid nodules covered by urothelium. Both tumors had glandular architecture. One tumor had regular bland nuclei, and the other had focal moderate nuclear pleomorphism. Neuroendocrine differentiation was readily confirmed by the immunohistochemical markers chromogranin, synaptophysin, and neural cell adhesion molecule (CD56/NCAM). In 1 of the tumors, 20% of the cells were positive for the beta subunit of human chorionic gonadotropin, and 20% were positive for thyroid transcription factor 1.
我们报告了2例膀胱类癌肿瘤的临床、组织病理学和免疫表型特征，并对相关文献进行了综述。这两个肿瘤均位于膀胱颈部，表现为血尿，体积较小，经膀胱镜检查似乎已完全切除。肿瘤表面光滑，为无蒂息肉样结节，被尿路上皮覆盖。两个肿瘤均具有腺管状结构。一个肿瘤的细胞核规则、形态温和，另一个肿瘤有局灶性中度核异型性。通过免疫组化标记物嗜铬粒蛋白、突触素和神经细胞黏附分子（CD56/NCAM）很容易证实神经内分泌分化。在其中一个肿瘤中，20%的细胞人绒毛膜促性腺激素β亚基呈阳性，20%的细胞甲状腺转录因子1呈阳性。
