Hocker Geoffrey A
J R Soc Med. 2003 Feb;96(2):70-3. doi: 10.1258/jrsm.96.2.70.
How does an area of sensory cortex recognize the specific nature of the sensory mode of the stimulus that arrives from the peripheral sensory receptor, when nerve impulses are only all-or-nothing action potentials? Work in animals has shown that an area of sensory cortex can learn in which mode to respond. A period of cortical learning is required for phantom limb phenomena to develop, and for the ocular blind to dream in the visual mode. Arguing from these facts I develop the hypothesis that within the sensory cortices there are neurons that learn by neurotropic factor transport from their sensory receptors to function as surrogates for those receptors, thus enabling sensory cortical response to be modally specific.
当神经冲动只是全或无的动作电位时,感觉皮层的一个区域如何识别从外周感觉感受器传来的刺激的特定感觉模式性质呢?对动物的研究表明,感觉皮层的一个区域可以学习以哪种模式做出反应。幻肢现象的出现以及盲人在视觉模式下做梦都需要一段皮层学习期。基于这些事实,我提出一个假说:在感觉皮层内存在一些神经元,它们通过神经营养因子从感觉感受器的转运来学习,从而充当那些感受器的替代物,进而使感觉皮层的反应具有模式特异性。