Germiniani Francisco Manoel B, Roriz Mauricio, Nabhan Samir K, Teive Helio A G, Werneck Lineu C
Serviço de Neurologia, Departamento de Clinica Medica, Hospital de Clinicas da Universidade Federal do Parana, Curitiba, PR, Brasil.
Arq Neuropsiquiatr. 2002 Dec;60(4):1030-3. doi: 10.1590/s0004-282x2002000600028. Epub 2003 Jan 15.
Central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM) are different presentations of a demyelinating disorder of the brain more commonly associated with rapid correction of hyponatremia, spastic tetraparesia and pseudo-bulbar palsy. There are in the literature a few cases of CPM/EPM in patients without electrolyte disturbances. We report the case of a 39 year-old man with severe alcoholism, who presented with spastic tetraparesis and palsy of several cranial nerves, associated with lesions in the magnetic resonance compatible with CPM/EPM. The patient had a good follow-up after pulse therapy with corticosteroids.
中央桥脑髓鞘溶解症(CPM)和脑桥外髓鞘溶解症(EPM)是一种脑部脱髓鞘疾病的不同表现形式,更常与低钠血症的快速纠正、痉挛性四肢轻瘫和假性球麻痹相关。文献中有一些无电解质紊乱患者发生CPM/EPM的病例。我们报告一例39岁重度酒精中毒男性患者,其表现为痉挛性四肢轻瘫和多条颅神经麻痹,磁共振成像显示的病变符合CPM/EPM。该患者接受皮质类固醇脉冲治疗后随访情况良好。