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[一名无水电解质紊乱的酒精性患者发生的中央桥脑和脑桥外髓鞘溶解症:病例报告]

[Central pontine and extra-pontine myelinolysis in an alcoholic patient without hydro-electrolyte disturbances: case report].

作者信息

Germiniani Francisco Manoel B, Roriz Mauricio, Nabhan Samir K, Teive Helio A G, Werneck Lineu C

机构信息

Serviço de Neurologia, Departamento de Clinica Medica, Hospital de Clinicas da Universidade Federal do Parana, Curitiba, PR, Brasil.

出版信息

Arq Neuropsiquiatr. 2002 Dec;60(4):1030-3. doi: 10.1590/s0004-282x2002000600028. Epub 2003 Jan 15.

Abstract

Central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM) are different presentations of a demyelinating disorder of the brain more commonly associated with rapid correction of hyponatremia, spastic tetraparesia and pseudo-bulbar palsy. There are in the literature a few cases of CPM/EPM in patients without electrolyte disturbances. We report the case of a 39 year-old man with severe alcoholism, who presented with spastic tetraparesis and palsy of several cranial nerves, associated with lesions in the magnetic resonance compatible with CPM/EPM. The patient had a good follow-up after pulse therapy with corticosteroids.

摘要

中央桥脑髓鞘溶解症(CPM)和脑桥外髓鞘溶解症(EPM)是一种脑部脱髓鞘疾病的不同表现形式,更常与低钠血症的快速纠正、痉挛性四肢轻瘫和假性球麻痹相关。文献中有一些无电解质紊乱患者发生CPM/EPM的病例。我们报告一例39岁重度酒精中毒男性患者,其表现为痉挛性四肢轻瘫和多条颅神经麻痹,磁共振成像显示的病变符合CPM/EPM。该患者接受皮质类固醇脉冲治疗后随访情况良好。

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