Osorio Lyda, Ferro Beatriz E, Castillo Carmen M
London School of Hygiene and Tropical Medicine, London, UK.
Mem Inst Oswaldo Cruz. 2002 Dec;97(8):1221-3. doi: 10.1590/s0074-02762002000800026. Epub 2003 Jan 20.
The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP). The overall proportion of gametocyte carriers was high (85%) and not statistically significantly different between the CQ and SP treatment groups. However, an increased risk of carrying gametocytes on day 14 of follow up (1.26 95% CI 1.10-1.45) was found among patients having therapeutic failure to CQ compared with patients having an adequate therapeutic response. This finding confirms and extends reports of increased risk of gametocytaemia among CQ resistant P. falciparum.
抗疟药对配子体的影响会影响传播及耐药性的扩散。为了进一步了解这种关系，我们确定了接受氯喹（CQ）或磺胺多辛/乙胺嘧啶（SP）治疗的非复杂性恶性疟原虫疟疾患者治疗后不同时间点配子体携带者的比例。配子体携带者的总体比例较高（85%），CQ和SP治疗组之间无统计学显著差异。然而，与治疗反应良好的患者相比，CQ治疗失败的患者在随访第14天携带配子体的风险增加（1.26，95%可信区间1.10 - 1.45）。这一发现证实并扩展了关于对CQ耐药的恶性疟原虫配子血症风险增加的报道。
