Chou Chung T, Chen Jia M, Hsu Chang M, Chen Shu J
Division of Allergy-Immunology-Rheumatology, Veterans General Hospital, Taipei, Taiwan.
J Rheumatol. 2003 Feb;30(2):321-5.
We surveyed B27 and its subtypes in 5 ethnic groups in Taiwan.
Blood was obtained from 281 Aborigine people of the Atayal tribe (I-Lan), 141 Paiwan (Ping-Ton), 38 Rukai (Ping-Ton), and 40 Yami (Orchid Island), and also 47 B27+ healthy Han Chinese subjects and 82 B27+ Han patients with ankylosing spondylitis (AS). HLA-B27 and its subtypes were determined by standard methods.
A much higher prevalence of B27 was found among the Atayal Aborigines (9.2%), which was significantly different from a lower prevalence in the Paiwan (2.1%; p = 0.004) and even higher than that of Han Chinese (5.59%; p = 0.04). No blood sample from the 38 Rukai Aborigines showed any B27. B2704 was the only subtype (100%) found in the 28 healthy Aborigines and 2 Aborigine patients with AS. However, in Chinese subjects, 40 of 47 (85%) B27+ healthy subjects were B2704, and 7 of 47 (15%) were B2705. In Chinese B27+ AS patients, 77 of 82 (94%) were B2704 and 5 of 82 (6%) were B2705. No other subtypes were found. Only the Aborigines without AS carrying B2704 showed a significant difference from the Chinese without AS carrying B2704 (p = 0.041).
The different prevalence of B27, but similar frequency of the B2704 subtype, between Aborigines and Han Chinese suggests Aborigines are a unique population and may originate from an Asian country, possibly mainland China.
我们对台湾5个民族的B27及其亚型进行了调查。
采集了281名泰雅族原住民（宜兰）、141名排湾族（屏东）、38名鲁凯族（屏东）和40名雅美族（兰屿）的血液，以及47名B27阳性的健康汉族受试者和82名B27阳性的汉族强直性脊柱炎（AS）患者的血液。采用标准方法测定HLA - B27及其亚型。
泰雅族原住民中B27的患病率较高（9.2%），与排湾族较低的患病率（2.1%；p = 0.004）有显著差异，甚至高于汉族（5.59%；p = 0.04）。38名鲁凯族原住民的血液样本均未显示B27阳性。B2704是在28名健康原住民和2名原住民AS患者中发现的唯一亚型（100%）。然而，在汉族受试者中，47名B27阳性健康受试者中有40名（85%）为B2704，47名中有7名（15%）为B2705。在汉族B27阳性AS患者中，82名中有77名（94%）为B2704，82名中有5名（6%）为B2705。未发现其他亚型。仅携带B2704的非AS原住民与携带B2704的非AS汉族之间存在显著差异（p = 0.041）。
原住民和汉族之间B27患病率不同，但B2704亚型频率相似，这表明原住民是一个独特的群体，可能起源于亚洲国家，可能是中国大陆。
