Minchinton R M, Doyle D V, Waters A H
Clin Lab Haematol. 1982;4(2):131-8.
In a study of eight patients with Felty's syndrome, surface-bound immunoglobulin (IgG +/- IgM and complement) was demonstrated in all cases by a fluorescein-labelled antihuman globulin technique using paraformaldehyde-fixed neutrophils to prevent non-specific surface adsorption of immunoglobulin. The test was negative in control patients with rheumatoid arthritis alone. The neutrophil binding of immunoglobulin occurred in vivo and could not be reproduced with the patient's serum and normal neutrophils. The presence of alloantibodies due to previous pregnancy or transfusion can obscure this picture. A neutrophil autoantibody or cell-bound immune complexes may be the cause of this phenomenon, which may be a useful marker of Felty's syndrome in patients with rheumatoid arthritis.
在一项针对8例费尔蒂综合征患者的研究中，通过使用多聚甲醛固定的中性粒细胞以防止免疫球蛋白的非特异性表面吸附的荧光素标记抗人球蛋白技术，在所有病例中均证实了表面结合免疫球蛋白（IgG +/- IgM和补体）。仅患类风湿关节炎的对照患者该检测为阴性。免疫球蛋白与中性粒细胞的结合发生在体内，并且用患者的血清和正常中性粒细胞无法重现这种情况。既往妊娠或输血导致的同种异体抗体的存在可能会掩盖这种情况。中性粒细胞自身抗体或细胞结合免疫复合物可能是这种现象的原因，这可能是类风湿关节炎患者费尔蒂综合征的一个有用标志物。
