Xu M, Zhang S, Li S, Wang T, Chen J, Ou N, Fang G, Wang Q, Li J, Zhang X
Anhui Provincial Institute of Schistosomiasis, Wuhu 241000.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(4):241-3.
To assess the preventive effect of oral artesunate against S. japonicum infection.
Residents in two pilots in the schistosomiasis endemic regions, 562 cases in Yanghe pilot, Wangjiang County and 218 cases in Shashan pilot, Guichi City, Anhui Province, were selected for this study. The residents were divided into two groups. Group I received artesunate 6 mg/kg once every 2 weeks for 4 times 2 wk after contacting with infested water from July to September in 1997. Group II received the same dosage of placebo at the corresponding times. Four weeks after the last administration, stool examination using hatching method and Kato's method was conducted to evaluate the effect.
In Yanghe pilot, 2 cases were hatching positive in the artesunate-treated group with an infection rate of 0.7% (2/273), while 11 cases were stool positive in placebo group with an infection rate of 3.8% (11/289) and a mean EPG of 26.40 +/- 1.49. In Shashan pilot, all cases in artesunate-treated group were stool negative, while 7 cases were stool positive in the placebo group with an infection rate of 6.3% (7/111), and a mean EPG of 14.23 +/- 2.14. The protection rate of artesunate was 80.9% and 100%, respectively, in the two pilots.
Artesunate can protect the residents from S. japonicum infection effectively.
评估口服青蒿琥酯对日本血吸虫感染的预防效果。
选取血吸虫病流行区两个试点的居民，安徽省望江县洋河试点562例，池州市贵池区沙山试点218例，纳入本研究。将居民分为两组。1997年7月至9月接触疫水2周后，第一组每2周口服青蒿琥酯6mg/kg，共4次。第二组在相应时间给予相同剂量的安慰剂。末次给药4周后，采用孵化法和加藤法进行粪便检查以评估效果。
在洋河试点，青蒿琥酯治疗组有2例孵化阳性，感染率为0.7%（2/273），而安慰剂组有11例粪便阳性，感染率为3.8%（11/289），平均每克粪便虫卵数（EPG）为26.40±1.49。在沙山试点，青蒿琥酯治疗组所有病例粪便均为阴性，而安慰剂组有7例粪便阳性，感染率为6.3%（7/111），平均EPG为14.23±2.14。青蒿琥酯在两个试点的保护率分别为80.9%和100%。
青蒿琥酯能有效保护居民免受日本血吸虫感染。
