[The expression of transforming growth factor alpha and its receptor in nasal polyps].
作者信息
Chen F Q, Huang W G, Qiao L, Jiang H Y
机构信息
Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Nov;14(11):483-4.
PMID:12563935
Abstract
OBJECTIVE
To assess the possible role of expression of TGF alpha and EGFR in nasal polyps and its relationship with PCNA labeling index.
METHOD
Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.
RESULT
The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.
CONCLUSION
TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.
摘要
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