Nakagawa T, Yamane H, Nakai Y, Shigeta T, Takashima T, Takeda Z
Department of Otorhinolaryngology, Yodogawa Christian Hospital, Osaka, Japan.
Acta Otolaryngol Suppl. 1998;538:205-8. doi: 10.1080/00016489850182945.
In nasal polyps constantly associated with chronic inflammation, a dysregulation of epithelial cell proliferation has been described. Involvement of extracellular matrix accumulation is also suggested in the formation and growth of nasal polyps. In this study, we attempted to evaluate the activity of the proliferation of epithelial cells and fibroblasts and the relation between fibronectin accumulation and these cell proliferations in nasal polyps. The pathological specimens of 30 patients were examined which manifested proliferating cell nuclear antigen (PCNA) expression in epithelial cells and fibroblasts and in fibronectin expression. PCNA expression was quantified by calculating the index for each sample. No significant difference in PCNA index was found between epithelial cells and fibroblasts. However, a significant correlation was found between the epithelial and fibroblastic PCNA index. In addition, fibronectin immunopositivity was well correlated with the activity of proliferation of fibroblasts. Therefore, proliferation of fibroblasts is also an important factor in the growth of nasal polyps, and its relationship with fibronectin accumulation may play a role in the pathogenesis of nasal polyposis.
在与慢性炎症持续相关的鼻息肉中，已描述了上皮细胞增殖的失调。鼻息肉的形成和生长中也提示有细胞外基质积聚的参与。在本研究中，我们试图评估鼻息肉中上皮细胞和成纤维细胞的增殖活性以及纤连蛋白积聚与这些细胞增殖之间的关系。检查了30例患者的病理标本，这些标本显示了上皮细胞、成纤维细胞中增殖细胞核抗原（PCNA）的表达以及纤连蛋白的表达。通过计算每个样本的指数来定量PCNA表达。上皮细胞和成纤维细胞之间的PCNA指数未发现显著差异。然而，上皮和成纤维细胞的PCNA指数之间发现有显著相关性。此外，纤连蛋白免疫阳性与成纤维细胞的增殖活性密切相关。因此，成纤维细胞的增殖也是鼻息肉生长的一个重要因素，其与纤连蛋白积聚的关系可能在鼻息肉病的发病机制中起作用。
