Sato Tsuneo, Higuchi Tomomi, Shibuya Hisashi, Ohba Shigeo, Nogami Sadao, Shirai Wataru, Watanabe Hideaki, Honda Shigeaki
Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.
J Zoo Wildl Med. 2002 Dec;33(4):367-70. doi: 10.1638/1042-7260(2002)033[0367:LSCCIA]2.0.CO;2.
A 28-yr-old female California sea lion (Zalophus californianus) in a commercial aquarium developed an ulcerated lingual tumor and died. Necropsy revealed a moderately differentiated squamous cell carcinoma. Immunohistochemical staining and electron microscopic studies revealed that the tumor cells were strongly positive with anti-keratin-cytokeratin antibody and had abundant tonofibrils and desmosomes. The neoplasm had metastasized to a mandibular lymph node.
一只28岁的雌性加利福尼亚海狮（加州海狗）在一家商业水族馆中患上了溃疡性舌肿瘤并死亡。尸检显示为中度分化的鳞状细胞癌。免疫组织化学染色和电子显微镜研究表明，肿瘤细胞对抗角蛋白-细胞角蛋白抗体呈强阳性，且有丰富的张力原纤维和桥粒。肿瘤已转移至下颌淋巴结。
