Campbell Vicki L, Drobatz Kenneth J, Perkowski Sandra Z
Section of Anesthesia and Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Am Vet Med Assoc. 2003 Feb 1;222(3):330-6. doi: 10.2460/javma.2003.222.330.
To determine frequency and severity of postanesthetic hypoxemia and hypercarbia in healthy dogs undergoing elective ovariohysterectomy or castration and given butorphanol or hydromorphone for analgesia.
Prospective trial.
0 healthy dogs weighing > 10 kg (22 lb).
Dogs were anesthestized with acepromazine, glycopyrrolate, thiopental, and isoflurane, and butorphanol (n = 10) or hydromorphone (10) was used for perioperative analgesia. Arterial blood gas analyses were performed 10 and 30 minutes and 1, 2, 3, and 4 hours after extubation.
In dogs that received hydromorphone, mean PaCO2 was significantly higher, compared with the preoperative value, 10 and 30 minutes and 1, 2, and 3 hours after extubation. Mean PaCO2 was significantly higher in dogs given hydromorphone rather than butorphanol 10 and 30 minutes and 1 and 2 hours after extubation. Mean PaO2 was significantly lower, compared with preoperative values, 30 minutes and 1 and 2 hours after extubation in dogs given hydromorphone and 30 minutes after extubation in dogs given butorphanol. Mean PaO2 was significantly lower in dogs given hydromorphone rather than butorphanol 1 hour after extubation. Four dogs had PaO2 < 80 mm Hg 1 or more times after extubation.
Results suggest that administration of hydromorphone to healthy dogs undergoing elective ovariohysterectomy or castration may result in transient increases in PaCO2 postoperatively and that administration of hydromorphone or butorphanol may result in transient decreases in PaO2. However, increases in PaCO2 and decreases in PaO2 were mild, and mean PaCO2 and PaO2 remained within reference limits.
确定接受择期卵巢子宫切除术或去势手术并给予布托啡诺或氢吗啡酮镇痛的健康犬麻醉后低氧血症和高碳酸血症的发生率及严重程度。
前瞻性试验。
40只体重>10千克（22磅）的健康犬。
犬只使用乙酰丙嗪、格隆溴铵、硫喷妥钠和异氟烷进行麻醉，布托啡诺（n = 20）或氢吗啡酮（20）用于围手术期镇痛。拔管后10分钟、30分钟以及1、2、3和4小时进行动脉血气分析。
接受氢吗啡酮的犬只，拔管后10分钟、30分钟以及1、2和3小时，平均动脉血二氧化碳分压（PaCO2）与术前值相比显著升高。拔管后10分钟、30分钟以及1和2小时，接受氢吗啡酮的犬只平均PaCO2显著高于接受布托啡诺的犬只。接受氢吗啡酮的犬只，拔管后30分钟以及1和2小时，平均动脉血氧分压（PaO2）与术前值相比显著降低；接受布托啡诺的犬只，拔管后30分钟时PaO2显著降低。拔管后1小时，接受氢吗啡酮的犬只平均PaO2显著低于接受布托啡诺的犬只。4只犬拔管后PaO2有1次或多次<80毫米汞柱。
结果表明，对接受择期卵巢子宫切除术或去势手术的健康犬给予氢吗啡酮可能导致术后PaCO2短暂升高，给予氢吗啡酮或布托啡诺可能导致PaO2短暂降低。然而，PaCO2升高和PaO2降低程度较轻，平均PaCO2和PaO2仍在参考范围内。
