布托啡诺或氟罗昔康对接受择期卵巢子宫切除术的犬的术后镇痛效果。

Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy.

作者信息

Camargo Janaina B, Steagall Paulo V M, Minto Bruno W, Lorena Sílvia Elaine Rodolfo de Sá, Mori Eduardo S, Luna Stelio P L

机构信息

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, Sao Paulo State University, UNESP Botucatu, São Paulo, Brazil.

出版信息

Vet Anaesth Analg. 2011 May;38(3):252-9. doi: 10.1111/j.1467-2995.2011.00609.x.

DOI:10.1111/j.1467-2995.2011.00609.x

PMID:21492391

Abstract

OBJECTIVE

To compare the post-operative analgesic effects of butorphanol or firocoxib in dogs undergoing ovariohysterectomy.

STUDY DESIGN

Prospective, randomized, blinded, clinical trial.

ANIMALS

Twenty-five dogs >1 year of age.

METHODS

Dogs received acepromazine intramuscularly (IM), 0.05 mg kg(-1) and either butorphanol IM, 0.2 mg kg(-1) (BG, n = 12) or firocoxib orally (PO), 5 mg kg(-1) (FG, n = 13), approximately 30 minutes before induction of anesthesia with propofol. Anesthesia was maintained with isoflurane. Ovariohysterectomy was performed by the same surgeon. Pain scores using the dynamic and interactive visual analog scale (DIVAS) were performed before and at 1, 2, 3, 4, 6, 8 and 20 hours after the end of surgery by one observer, blinded to the treatment. Rescue analgesia was provided with morphine (0.5 mg kg(-1)) IM and firocoxib, 5 mg kg(-1) (BG only) PO if DIVAS >50. Groups were compared using paired t-tests and Fisher's exact test (p < 0.05). Data are presented as mean ± SD.

RESULTS

The BG required significantly less propofol (BG: 2.6 ± 0.59 mg kg(-1); FG: 5.39 ± 0.7 mg kg(-1)) (p < 0.05) but the anesthesia time was longer (BG: 14 ± 6, FG: 10 ± 4 minutes). There were no differences for body weight (BG: 7.9 ± 5.0, FG: 11.5 ± 4.6 kg), sedation scores, and surgery and extubation times (BG: 10 ± 2, 8 ± 5 minutes; FG: 9 ± 3, 8 ± 4 minutes, respectively) (p > 0.05). The FG had significantly lower pain scores than the BG at 1, 2 and 3 hours following surgery (p < 0.05). Rescue analgesia was administered to 11/12 (92%) and 2/13 (15%) dogs in the BG and FG, respectively (p < 0.05).

CONCLUSION AND CLINICAL RELEVANCE

Firocoxib produced better post-operative analgesia than butorphanol. Firocoxib may be used as part of a multimodal analgesia protocol but may not be effective as a sole analgesic.

摘要

目的

比较布托啡诺或非罗考昔对接受卵巢子宫切除术的犬的术后镇痛效果。

研究设计

前瞻性、随机、双盲临床试验。

动物

25只年龄大于1岁的犬。

方法

犬在使用丙泊酚诱导麻醉前约30分钟，肌肉注射（IM）0.05 mg/kg的乙酰丙嗪，然后分别肌肉注射0.2 mg/kg的布托啡诺（BG组，n = 12）或口服（PO）5 mg/kg的非罗考昔（FG组，n = 13）。使用异氟烷维持麻醉。卵巢子宫切除术由同一位外科医生进行。由一名对治疗不知情的观察者在手术结束前及结束后1、2、3、4、6、8和20小时，使用动态交互式视觉模拟量表（DIVAS）进行疼痛评分。如果DIVAS评分>50，则对BG组犬肌肉注射吗啡（0.5 mg/kg）并口服5 mg/kg的非罗考昔（仅BG组）进行解救镇痛。使用配对t检验和Fisher精确检验对组间进行比较（p < 0.05）。数据以平均值±标准差表示。

结果

BG组所需丙泊酚显著较少（BG组：2.6±0.59 mg/kg；FG组：5.39±0.7 mg/kg）（p < 0.05），但麻醉时间较长（BG组：14±6分钟，FG组：10±4分钟）。体重（BG组：7.9±5.0 kg，FG组：11.5±4.6 kg）、镇静评分、手术及拔管时间（BG组分别为10±2分钟、8±5分钟；FG组分别为9±3分钟、8±4分钟）无差异（p > 0.05）。术后1、2和3小时，FG组的疼痛评分显著低于BG组（p < 0.05）。BG组和FG组分别有11/12（92%）和2/13（15%）的犬接受了解救镇痛（p < 0.05）。