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疯牛病——披着羊皮的狼?

BSE - a wolf in sheep's clothing?

作者信息

Baylis Matthew, Houston Fiona, Kao Rowland R, McLean Angela R, Hunter Nora, Gravenor Mike B

机构信息

Institute for Animal Health, Compton Laboratory, Newbury, Berkshire, UK RG20 7NN.

出版信息

Trends Microbiol. 2002 Dec;10(12):563-70. doi: 10.1016/s0966-842x(02)02477-0.

DOI:10.1016/s0966-842x(02)02477-0
PMID:12564992
Abstract

The entire sheep flock in the UK has been threatened with slaughter if BSE is found in farmed sheep, largely on the grounds that an epidemic of BSE in sheep could be harder to contain than was the case for cattle, and that lamb could present a greater risk to consumers than beef. However, identifying BSE in a sheep is not straightforward, because of its similarities to the related disease, scrapie. Here, we review the likelihood that any UK sheep have BSE, how they might have got it, how a case could be identified and what the Government is doing in terms of surveillance and possible control methods.

摘要

如果在养殖绵羊中发现疯牛病,英国的整个羊群都面临被屠宰的威胁,主要原因是绵羊的疯牛病疫情可能比牛的疫情更难控制,而且羊肉对消费者构成的风险可能比牛肉更大。然而,由于绵羊疯牛病与相关疾病羊瘙痒病相似,因此识别绵羊疯牛病并非易事。在此,我们将审视英国绵羊感染疯牛病的可能性、它们可能的感染途径、如何识别病例以及政府在监测和可能的控制方法方面正在采取的措施。

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BSE - a wolf in sheep's clothing?疯牛病——披着羊皮的狼?
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Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases.绵羊和山羊的经典型和非典型性瘙痒病。两种疾病的病因、遗传因素、发病机制、诊断及防控措施综述
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J Genet. 2018 Jun;97(2):453-461.
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Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie.
野生型小鼠生物测定法在存在过量瘙痒病的情况下检测牛海绵状脑病(BSE)的能力。
Acta Neuropathol Commun. 2015 Apr 3;3:21. doi: 10.1186/s40478-015-0194-2.
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An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie.临床前检测策略与控制经典羊瘙痒病的强制性羊群淘汰计划的经济学评估。
PLoS One. 2012;7(3):e32884. doi: 10.1371/journal.pone.0032884. Epub 2012 Mar 7.
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Detection and localisation of PrP(Sc) in the liver of sheep infected with scrapie and bovine spongiform encephalopathy.检测和定位感染羊瘙痒病和牛海绵状脑病的绵羊肝脏中的朊病毒(PrP(Sc))。
PLoS One. 2011 May 12;6(5):e19737. doi: 10.1371/journal.pone.0019737.
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Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice.绵羊和山羊 BSE 在人类 PrP 转基因小鼠中比牛 BSE 更有效地传播。
PLoS Pathog. 2011 Mar;7(3):e1001319. doi: 10.1371/journal.ppat.1001319. Epub 2011 Mar 17.
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Use of a preclinical test in the control of classical scrapie.临床前试验在控制经典羊瘙痒病中的应用。
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Comparison of strategies for substantiating freedom from scrapie in a sheep flock.羊群中证明无痒病策略的比较。
BMC Vet Res. 2009 Apr 30;5:16. doi: 10.1186/1746-6148-5-16.
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A descriptive study of the prevalence of atypical and classical scrapie in sheep in 20 European countries.对20个欧洲国家绵羊非典型和经典痒病流行情况的描述性研究。
BMC Vet Res. 2008 Jun 10;4:19. doi: 10.1186/1746-6148-4-19.
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