肺转移性眼内腺癌患者房水中白细胞介素-6水平升高。
Increased interleukin-6 in aqueous humor of a patient with lung-metastatic intraocular adenocarcinoma.
作者信息
Chen Ko-Hua, Hsu Wen-Ming, Wu Chih-Chiau
机构信息
Department of Ophthalmology, Taipei Veterans General Hospital, Section II, Taipei, Taiwan, Republic of China.
出版信息
Am J Ophthalmol. 2003 Feb;135(2):237-9. doi: 10.1016/s0002-9394(02)01920-7.
PURPOSE
We report increased interleukin (IL)-6 level in aqueous humor of a case of lung adenocarcinoma with metastasis to iris and anterior chamber.
DESIGN
Interventional case report.
METHODS
In one case and 11 healthy cataract patients as controls, we checked the levels of IL-6, IL-2, and tumor necrosis factor (TNF)-alpha in aqueous humor and serum by enzyme-linked immunosorbent assay.
RESULTS
Levels of these three cytokines in serum were almost the same as with the levels in aqueous humor in the control group. The IL-6 concentrations ranged from 12.6 to 27.0 pg/ml (mean, 23.5 pg/ml) in serum and 15.0 to 43.1 pg/ml (mean, 22.4 pg/ml) in aqueous humor. There was no statistically significant difference between them. Compared with the control, the IL-6 concentration in aqueous humor of this patient, 282.0 pg/ml, increased more than 10-fold.
CONCLUSION
This is a report describing elevated IL-6 level in the aqueous humor of a patient with intraocular metastasis from lung adenocarcinoma.
目的
我们报告了一例发生虹膜和前房转移的肺腺癌患者房水中白细胞介素（IL）-6水平升高的情况。
设计
介入性病例报告。
方法
选取1例患者及11例健康白内障患者作为对照，采用酶联免疫吸附测定法检测房水和血清中IL-6、IL-2及肿瘤坏死因子（TNF）-α的水平。
结果
对照组血清中这三种细胞因子的水平与房水中的水平几乎相同。血清中IL-6浓度范围为12.6至27.0 pg/ml（平均23.5 pg/ml），房水中为15.0至43.1 pg/ml（平均22.4 pg/ml）。两者之间无统计学显著差异。与对照组相比，该患者房水中IL-6浓度为282.0 pg/ml，升高了10倍以上。
结论
本文报告了一例肺腺癌眼内转移患者房水中IL-6水平升高的情况。
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