Martin Sophie, Favot Laure, Matz Rachel, Lugnier Claire, Andriantsitohaina Ramaroson
Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, Faculté de Pharmacie, Université Louis Pasteur, 74 route du Rhin, BP 24, 67401 Illkirch, France.
Biochem Pharmacol. 2003 Feb 15;65(4):669-75. doi: 10.1016/s0006-2952(02)01568-x.
Epidemiological studies have shown that a diet rich in fruits and vegetables might reduce the risk of cardiovascular diseases and protect against cancer by mechanisms that have not been elucidated yet. This study was aimed to define the effect of delphinidin, a vasoactive polyphenol belonging to the class of anthocyanin, on bovine aortic endothelial cells (BAECs) proliferation. Delphinidin inhibited serum- and vascular endothelium growth factor-induced BAECs proliferation. This antiproliferative effect of delphinidin, is triggered by ERK-1/-2 activation, independent of nitric oxide pathway and is correlated with suppression of cell progression by blocking the cell cycle in G(0)/G(1) phase. Furthermore, suppression of cell cycle progression is associated with the modulation of the mitogenic signaling transduction cascade. This includes over-expression of caveolin-1 and p21(WAF1/Cip1) and down-expression of Ras and cyclin D1. In conclusion, the antiproliferative effect of delphinidin may be of importance in preventing both plaque development and stability in atherosclerosis and tumor dissemination in cancer.
流行病学研究表明，富含水果和蔬菜的饮食可能会降低心血管疾病的风险，并通过尚未阐明的机制预防癌症。本研究旨在确定花青素类血管活性多酚——飞燕草素对牛主动脉内皮细胞（BAECs）增殖的影响。飞燕草素抑制血清和血管内皮生长因子诱导的BAECs增殖。飞燕草素的这种抗增殖作用是由ERK-1/-2激活触发的，与一氧化氮途径无关，并且与通过在G(0)/G(1)期阻断细胞周期来抑制细胞进程相关。此外，细胞周期进程的抑制与促有丝分裂信号转导级联的调节有关。这包括小窝蛋白-1和p21(WAF1/Cip1)的过表达以及Ras和细胞周期蛋白D1的下调。总之，飞燕草素的抗增殖作用在预防动脉粥样硬化中的斑块形成和稳定性以及癌症中的肿瘤扩散方面可能具有重要意义。
