Xiong Li-juan, Luo Duan-de, Zeng Lin-lan, Li Shu-li
Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(4):209-11.
To study the effect of pentoxifylline (PTX) on the content of hepatic TGF-beta 1, type I and type III collagen in schistosome-infected mice with liver fibrosis.
Forty mice with schistosomiasis were divided into four groups: one group as control without any treatment, other three were treated with praziquantel 500 mg/(kg.d) for 2 d, high dose PTX 360 mg/(kg.d) for 8 wk, and low dose PTX 180 mg/(kg.d) for 8 wk respectively. Immunohistochemical technique and multimedia color pathographic analysis system were applied to observe the content of hepatic TGF-beta 1, type I and type III collagen in mice infected with S. japonicum before and after treatment.
The effect of PTX on the content of hepatic TGF-beta 1, type I and type III collagen in mice was related to the dosage of PTX. High dose PTX treatment significantly reduced the content of TGF-beta 1, type I and type III collagen compared to the control (P < 0.01), whereas no difference was found between the group of low dose PTX treatment and control (P > 0.05).
High dose PTX treatment could reduce the content of hepatic TGF-beta 1, type I and type III collagen significantly in schistosome-infected mice with liver fibrosis.
研究己酮可可碱（PTX）对感染血吸虫的肝纤维化小鼠肝脏转化生长因子-β1（TGF-β1）、Ⅰ型和Ⅲ型胶原蛋白含量的影响。
将40只血吸虫病小鼠分为四组：一组为未作任何处理的对照组，其他三组分别用吡喹酮500mg/（kg·d）治疗2天、高剂量PTX 360mg/（kg·d）治疗8周、低剂量PTX 180mg/（kg·d）治疗8周。采用免疫组织化学技术和多媒体彩色病理图像分析系统观察日本血吸虫感染小鼠治疗前后肝脏TGF-β1、Ⅰ型和Ⅲ型胶原蛋白的含量。
PTX对小鼠肝脏TGF-β1、Ⅰ型和Ⅲ型胶原蛋白含量的影响与PTX剂量有关。与对照组相比，高剂量PTX治疗显著降低了TGF-β1、Ⅰ型和Ⅲ型胶原蛋白的含量（P<0.01），而低剂量PTX治疗组与对照组之间无差异（P>0.05）。
高剂量PTX治疗可显著降低感染血吸虫的肝纤维化小鼠肝脏TGF-β1、Ⅰ型和Ⅲ型胶原蛋白的含量。
