Wratten Mary Lou, Galaris Dimitrios, Tetta Ciro, Sevanian Alex
Clinical and Laboratory Research Department, Bellco, Mirandola (MO) Italy.
Antioxid Redox Signal. 2002 Dec;4(6):935-44. doi: 10.1089/152308602762197470.
End-stage renal disease patients have increased cardiovascular morbidity and mortality. These patients have many unique risk factors, such as an accumulation of uremic toxins, electrolyte imbalances, metabolic disturbances, anemia, chronic inflammation, and thrombogenic disturbances. Oxidative stress has been implicated in many of these disturbances. This review will focus on some of the factors that may accelerate cardiovascular disease in uremic patients, with an emphasis on mechanisms and interactions of various components of oxidative stress and inflammation. Understanding the mechanisms of these pathways may be useful in developing effective prevention and treatment strategies.
终末期肾病患者的心血管发病率和死亡率增加。这些患者有许多独特的危险因素，如尿毒症毒素蓄积、电解质失衡、代谢紊乱、贫血、慢性炎症和血栓形成紊乱。氧化应激与其中许多紊乱有关。本综述将聚焦于一些可能加速尿毒症患者心血管疾病的因素，重点关注氧化应激和炎症各成分的机制及相互作用。了解这些途径的机制可能有助于制定有效的预防和治疗策略。
