Le Duy T, Austin Ralph C, Payne S N P, Dworkin Michael J, Chappell M E
Department of Surgery, Southend General Hospital, Essex, United Kingdom.
Dis Colon Rectum. 2003 Feb;46(2):264-6. doi: 10.1007/s10350-004-6532-2.
Primary choriocarcinoma of the colon is a very rare tumor, with only six reported cases in the world literature, all but one of which was associated with an adjacent adenocarcinoma. This has led to the suggestion that colonic choriocarcinomas may arise from the more typical adenocarcinoma a process of further dedifferentiation. This article reviews the above cases and adds a further case from a 73-year-old male in whom no associated adenocarcinoma could be found despite careful postmortem examination. This finding gives support to the hypothesis that, rather than arising as a result of further dedifferentiation of an existing tumor, primary choriocarcinomas may also develop in the large intestine.
原发性结肠绒毛膜癌是一种极为罕见的肿瘤，世界文献中仅报道过6例，其中除1例之外，其余均与相邻腺癌相关。这使得有人提出，结肠绒毛膜癌可能源于更为典型的腺癌，是进一步去分化的过程。本文回顾了上述病例，并补充了1例来自一名73岁男性的病例，尽管经过仔细的尸检，仍未发现相关腺癌。这一发现支持了以下假说，即原发性绒毛膜癌并非由现有肿瘤进一步去分化产生，也可能在大肠中发生。
